Fig 3. Human mTOR kinase domain with docked XL765.

A. The mTOR kinase domain and XL765 are depicted in surface and red sticks representations. The binding site is blown-up and the interacting residues are labeled and presented in surface colored differently. B-C: Comparative binding analysis of XL765 (A) and the native ligand PI-103 (B). The hydrogen bonds are presented as green-dashed lines labeled with bond lengths and the residues participating in non-bonding interactions are presented as red arcs. The common interacting residues for both the ligands are encircled.