Table 4. Drug-likeness (Lipinski rule of five) for XL765 and the six proposed dual inhibitors 28, 18, 38, 9, 10, and 19.

Lipinski rule of five
Property	Desired value	XL765	28	18	38	9	10	19
Mol Wt.	<500	599.67	497.53	473.49	690.42	501.55	493.55	491.58
H-Bond Donors	<5	3	2	4	3	2	4	4
H-Bond Acceptors	<10	9	7	8	8	8	9	9
Rotatable Bonds	<10	10	6	6	7	8	6	6
Lipophilicity (LogP)	<5	5.76	4.29	3.53	4.73	4.14	3.42	3.18