Table 6. Interacting residues of PI3Kγ for the compounds XL765, 28, 18, 38, 9, 10, 19, and native ligand.
Each column has interacting residues of PI3Kγ for a particular compound whose name is mentioned in bold at the top in the first row. The interacting residues common with those of XL765 are shown in bold and italics.
| XL765 | 28 | 18 | 38 | 9 | 10 | 19 | Native |
|---|---|---|---|---|---|---|---|
| Lys-802 | - | - | - | - | - | - | - |
| Met-804 | Met-804 | Met-804 | Met-804 | - | Met-804 | - | Met-804 |
| - | - | Ala-805 | - | - | Ala-805 | Ala-805 | - |
| - | Ser-806 | Ser-806 | Ser-806 | Ser-806 | Ser-806 | Ser-806 | - |
| - | - | - | Lys-807 | Lys-807 | - | - | - |
| Trp-812 | Trp-812 | - | Trp-812 | - | - | - | Trp-812 |
| Ile-831 | Ile-831 | Ile-831 | - | Ile-831 | - | - | Ile-831 |
| - | - | Lys-833 | - | Lys-833 | Lys-833 | - | Lys-833 |
| - | - | Tyr-867 | - | - | Tyr-867 | - | Tyr-867 |
| - | Ile-879 | Ile-879 | Ile-879 | - | Ile-879 | - | Ile-879 |
| - | - | - | - | - | - | - | Glu-880 |
| - | - | - | - | - | - | - | Ile-881 |
| Val-882 | - | - | - | - | - | - | Val-882 |
| Ala-885 | Ala-885 | - | Ala-885 | - | - | - | - |
| Thr-886 | - | - | - | - | - | - | - |
| - | Thr-887 | Thr-887 | - | - | Thr-887 | - | Thr-887 |
| Lys-890 | Lys-890 | Lys-890 | Lys-890 | - | Lys-890 | Lys-890 | - |
| - | Asp-950 | Asp-950 | Asp-950 | - | Asp-950 | Asp-950 | - |
| - | Asn-951 | - | - | - | - | Asn-951 | - |
| Met-953 | Met-953 | Met-953 | Met-953 | - | Met-953 | - | Met-953 |
| Ile-963 | Ile-963 | Ile-963 | Ile-963 | - | Ile-963 | - | Ile-963 |
| - | Asp-964 | Asp-964 | Asp-964 | Asp-964 | Asp-964 | Asp-964 | Asp-964 |
| - | - | - | His-967 | His-967 | - | His-967 | - |
| - | - | - | - | His-1089 | - | - | - |
| - | - | - | Leu-1090 | Leu-1090 | - | Leu-1090 | - |
| - | - | - | - | Val-1091 | - | - | - |
| - | - | - | - | Leu-1092 | - | - | - |