Table 7. Interacting residues of mTOR for the compounds XL765, 28, 18, 38, 9, 10, 19, and native ligand.
Each column has interacting residues of mTOR for a particular compound whose name is mentioned in bold at the top in the first row. The interacting residues common with those of XL765 are shown in bold and italics.
| XL765 | 28 | 18 | 38 | 9 | 10 | 19 | Native |
|---|---|---|---|---|---|---|---|
| Ile-2163 | - | Ile-2163 | - | - | Ile-2163 | Ile-2163 | Ile-2163 |
| - | - | - | - | Thr-2164 | - | - | - |
| - | Ser-2165 | - | Ser-2165 | - | - | - | - |
| - | - | - | Lys-2166 | - | - | - | - |
| - | Gln-2167 | - | Gln-2167 | Gln-2167 | - | - | - |
| - | - | - | Pro-2169 | - | Pro-2169 | Pro-2169 | - |
| Leu-2185 | Leu-2185 | Leu-2185 | Leu-2185 | Leu-2185 | Leu-2185 | Leu-2185 | Leu-2185 |
| - | - | - | Lys-2187 | Lys-2187 | - | Lys-2187 | - |
| - | Glu-2190 | - | - | Glu-2190 | - | Glu-2190 | Glu-2190 |
| - | - | - | - | - | - | Leu-2192 | - |
| - | - | - | - | - | - | Asp-2195 | Asp-2195 |
| - | - | Tyr-2225 | - | - | Tyr-2225 | Tyr-2225 | Tyr-2225 |
| - | Ile-2237 | Ile-2237 | - | - | Ile-2237 | Ile-2237 | Ile-2237 |
| - | Gly-2238 | Gly-2238 | - | Gly-2238 | Gly-2238 | - | Gly-2238 |
| Trp-2239 | Trp-2239 | Trp-2239 | Trp-2239 | - | Trp-2239 | Trp-2239 | Trp-2239 |
| Val-2240 | Val-2240 | Val-2240 | - | Val-2240 | - | - | Val-2240 |
| - | - | Cys-2243 | - | - | - | - | - |
| Asp-2244 | - | Asp-2244 | - | - | - | - | - |
| Thr-2245 | - | Thr-2245 | Thr-2245 | - | - | - | - |
| - | - | His-2247 | - | - | His-2247 | - | - |
| Ala-2248 | - | Ala-2248 | - | - | - | - | - |
| Arg-2251 | - | Arg-2251 | - | - | - | - | - |
| Asp-2252 | - | - | - | - | - | - | - |
| - | - | Ser-2342 | - | - | Ser-2342 | - | - |
| Met-2345 | Met-2345 | - | Met-2345 | Met-2345 | Met-2345 | Met-2345 | - |
| Ile-2356 | Ile-2356 | Ile-2356 | Ile-2356 | Ile-2356 | Ile-2356 | Ile-2356 | Ile-2356 |
| - | Asp-2357 | - | - | Asp-2357 | - | Asp-2357 | Asp-2357 |