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. 2019 Apr 30;8:e43024. doi: 10.7554/eLife.43024

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© 2019, Kim et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Author response image 1. — (A) Schematic diagram for the experiments designed to demonstrate epithelial-stromal Hh/Bmp feedback loop. (B) Expression of Gli1, Bmp4, and Shh in mouse/human tumor organoids or cancer-associated fibroblasts treated with 5-Aza as described in (A). (C) Schematic diagram for the experiments to test off-target effects of 5-Aza in the stroma. (D) Expression of Shh in mouse/human tumor organoids cultured with or without cancer-associated fibroblasts as described in (C).