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. 2019 Jun 10;129(7):2745–2759. doi: 10.1172/JCI124738

Figure 5. Role of cell adhesion on mobilization.

Figure 5

(A–C) Mobilization in LFA1 (CD11a) and Mac1 (CD11b) knockout mice. CD11a-KO and CD11b-KO as well as WT C57BL/6J mice received an injection of PBS, tGro-β (2.5 mg/kg, s.c., time point 15 minutes), CWHM-823 (3.0 mg/kg, s.c., time point 60 minutes), or the 2 agents combined (dosed the same as for separate treatments, time point 30 minutes). Mobilization of WBCs (A), neutrophils (NEs) (B), and CFU-Cs (C) was assessed. Each bar is mean ± SEM, n = 4–8. ***P < 0.001, **P < 0.01, *P < 0.05. Statistical comparisons were made using ANOVA, followed by step-down Bonferroni’s adjustment for multiple comparisons.