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. 2019 Jun 10;129(7):2717–2729. doi: 10.1172/JCI126341

Figure 1. Dok3 negatively regulates antifungal immunity in vivo.

Figure 1

(A) Dok3+/+ (n = 14) and Dok3–/– (n = 12) mice were infected intravenously with 1 × 106 CFU of C. albicans. Survival was monitored over indicated time periods. Data were pooled from 3 independent experiments. ***P = 0.0007, log-rank test. (B) Kidneys were harvested for macroscopic analysis of fungal burden 2 days after infection (n = 5). (C) Analysis of kidney fungal burden by GMS and PAS staining 1 day after infection with 2.5 × 105 CFU of C. albicans. Arrows indicate fungal hyphae. Scale bars: 50 μm. Six sections per kidney were analyzed (n = 2). (D) Fungal titers of kidneys and brains were determined 2 days after infection. Symbols represent individual mice (n = 5). Data are shown as mean ± SEM. *P = 0.02; ***P = 0.0003, unpaired 2-tailed Student’s t test. One representative experiment out of 3 independent experiments is shown.