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. 2019 Jun 10;129(7):2717–2729. doi: 10.1172/JCI126341

Figure 7. Loss of Dok3 enhances neutrophil accumulation in Candida-infected brain.

Figure 7

(A) Flow cytometric analysis of neutrophils (Ly6G+Ly6C+) in kidneys and brains of Dok3+/+ and Dok3–/– mice 24 hours after infection with C. albicans. Dot plots are pregated on singlet, live CD45+ cells. (B) Total number of neutrophils in kidneys and brains of Dok3+/+ and Dok3–/– mice (n = 3–4). Data are shown as mean ± SEM. Two-way ANOVA demonstrated significant interaction between Dok3 expression and neutrophil numbers in the brain upon C. albicans infection (F[1,11] = 7.2; P = 0.02). *P = 0.02; **P = 0.002; ***P < 0.0001, 2-way ANOVA. (C) mRNA expression of indicated chemokines in homogenized brains expressed relative to the mean brain fungal burden of Dok3+/+ and Dok3–/– mice 24 hours after infection (n = 4). Data are shown as mean ± SEM. *P = 0.04, unpaired 2-tailed Student’s t test.