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. Author manuscript; available in PMC: 2019 Sep 27.
Published in final edited form as: Oncogene. 2019 Mar 27;38(26):5308–5320. doi: 10.1038/s41388-019-0794-6

Fig. 1. RAM2061 inhibits GGDPS in human and mouse PDAC cell lines.

Fig. 1.

a Chemical structure of the two GGDPS inhibitors used in these studies, VSW1198 and RAM2061. b and c Immunoblot analysis showing unmodified Rap1a in human (b) and mouse (c) PDAC cell lines treated with increasing concentrations of RAM2061 for 48 or 72 hours. β-tubulin is shown as a loading control. Immunoblots are representative of three independent experiments. d Levels of FPP and GGPP in human PDAC cell lines grown in the presence or absence of RAM2061 for 48 hours. (n = 3, data are displayed as mean ± stdev, *denotes p < 0.05. **denotes p < 0.01. ***denotes p < 0.001).