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. 2019 Jun 27;13(3):031501. doi: 10.1063/1.5100070

FIG. 3.

FIG. 3.

A lung-on-a-chip built with poly(lactic-co-glycolic acid) nanometer electrospinning as the supporting material was used to realize three-dimensional coculture of lung tumor cells. (a) Schematic diagram of microfluidic chip with PLGA nanofiber membrane as the substrate prepared by electrospinning. (b) Schematic diagram of the coculture of A549 cells, HFL1 cells, and HUVECs. (c) Schematic diagram of the coculture of three kinds of cells on the microchip. Fluorescence image of A549, HFL1, and HUVEC cells in the direction of the Z axis layer by layer. Time-lapse images of A549 cells and HUVECs in the Z direction at the same location at different times. Reproduced with permission from Yang et al., Lab Chip 18(3), 486–495 (2018). Copyright 2018 Royal Society of Chemistry.