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. Author manuscript; available in PMC: 2019 Jun 27.
Published in final edited form as: J Allergy Clin Immunol. 2015 Dec 10;137(3):813–21.e7. doi: 10.1016/j.jaci.2015.09.052

Table E4. Diagnostic sensitivity (true-positive rate) and specificity (true-negative rate) for cat or dog symptoms, respectively, and presence or absence of IgE reactivity to cat/dog extract or allergen molecules at 4, 8, and 16 years of age (n = 779).

Sensitivity Specificity
4 y
    Cat extract 43.2% (27.1% to 60.5%) 95.0% (93.2% to 96.5%)
    Any cat component 45.9% (29.5% to 63.1%) 92.6% (90.5% to 94.4%)
    Fel d 1 45.9% (29.5% to 63.1%) 93.1% (91.1% to 94.8%)
    Fel d 2 21.6% (9.83% to 38.2%) 99.3% (98.4% to 99.8%)
    Fel d 4   8.1% (1.7% to 21.9%) 99.1% (98.1% to 99.6%)
    Dog extract 45.8% (25.6% to 67.2%) 96.2% (94.5% to 97.4%)
    Any dog component 33.3% (15.6% to 55.3%) 97.4% (95.9% to 98.4%)
    Can f 1 25.0% (9.8% to 46.7%) 98.8% (97.7% to 99.5%)
    Can f 2 20.8% (7.1% to 42.2%) 99.7% (99.0% to 100%)
    Can f 3   4.2% (0.1% to 21.1%) 99.6% (98.8% to 99.9%)
    Can f 5 16.7% (4.7% to 37.4%) 98.5% (97.4% to 99.3%)
    Can f 6   8.3% (1.0% to 27.0%) 99.5% (98.6% to 99.9%)
8 y
    Cat extract 83.3% (70.7% to 92.1%) 91.2% (89.0% to 93.2%)
    Any cat component 83.6% (71.2% to 92.2%) 90.7% (88.4% to 92.8%)
    Fel d 1 83.6% (71.2% to 92.2%) 91.4% (89.2% to 93.4%)
    Fel d 2 38.2% (25.4% to 52.3%) 97.5% (96.1% to 98.5%)
    Fel d 4 16.4% (7.8% to 28.8%) 99.2% (98.2% to 99.7%)
    Dog extract 78.3% (56.3% to 92.5%) 90.4% (88.1% to 92.4%)
    Any dog component 75.0% (53.3% to 90.2%) 93.9% (92.0% to 95.5%)
    Can f 1 58.3% (36.6% to 77.9%) 98.4% (97.2% to 99.2%)
    Can f 2 16.7% (4.7% to 37.4%) 99.5% (98.6% to 99.9%)
    Can f 3 25.0% (9.8% to 46.7%) 99.6% (98.8% to 99.9%)
    Can f 5 50.0% (29.1% to 70.9%) 95.2% (93.5% to 96.6%)
    Can f 6 29.2% (12.6% to 51.1%) 99.2% (98.3% to 99.7%)
16 y
    Cat extract 80.5% (70.6% to 88.2%) 87.9% (85.2% to 90.2%)
    Any cat component 79.3% (69.3% to 87.3%) 85.4% (82.6% to 88.0%)
    Fel d 1 75.9% (65.5% to 84.4%) 86.7% (83.9% to 89.1%)
    Fel d 2 29.9% (20.5% to 40.6%) 95.8% (94.0% to 97.2%)
    Fel d 4 23.0% (14.6% to 33.2%) 97.4% (95.9% to 98.5%)
    Dog extract 76.7% (61.4% to 88.2%) 80.3% (77.2% to 83.1%)
    Any dog component 65.1% (49.1% to 79.0%) 88.2% (85.6% to 90.4%)
    Can f 1 44.2% (29.1% to 60.1%) 96.7% (95.2% to 97.9%)
    Can f 2   9.3% (2.6% to 22.1%) 99.2% (98.2% to 99.7%)
    Can f 3   9.3% (2.6% to 22.1%) 99.0% (98.1% to 99.6%)
    Can f 5 53.5% (37.7% to 68.8%) 89.8% (87.4% to 91.9%)
    Can f 6 25.6% (13.5% to 41.2%) 97.0% (95.5% to 98.1%)

Value are shown as proportions (95% CIs).