Table E4. Diagnostic sensitivity (true-positive rate) and specificity (true-negative rate) for cat or dog symptoms, respectively, and presence or absence of IgE reactivity to cat/dog extract or allergen molecules at 4, 8, and 16 years of age (n = 779).
| Sensitivity | Specificity | |
|---|---|---|
| 4 y | ||
| Cat extract | 43.2% (27.1% to 60.5%) | 95.0% (93.2% to 96.5%) |
| Any cat component | 45.9% (29.5% to 63.1%) | 92.6% (90.5% to 94.4%) |
| Fel d 1 | 45.9% (29.5% to 63.1%) | 93.1% (91.1% to 94.8%) |
| Fel d 2 | 21.6% (9.83% to 38.2%) | 99.3% (98.4% to 99.8%) |
| Fel d 4 | 8.1% (1.7% to 21.9%) | 99.1% (98.1% to 99.6%) |
| Dog extract | 45.8% (25.6% to 67.2%) | 96.2% (94.5% to 97.4%) |
| Any dog component | 33.3% (15.6% to 55.3%) | 97.4% (95.9% to 98.4%) |
| Can f 1 | 25.0% (9.8% to 46.7%) | 98.8% (97.7% to 99.5%) |
| Can f 2 | 20.8% (7.1% to 42.2%) | 99.7% (99.0% to 100%) |
| Can f 3 | 4.2% (0.1% to 21.1%) | 99.6% (98.8% to 99.9%) |
| Can f 5 | 16.7% (4.7% to 37.4%) | 98.5% (97.4% to 99.3%) |
| Can f 6 | 8.3% (1.0% to 27.0%) | 99.5% (98.6% to 99.9%) |
| 8 y | ||
| Cat extract | 83.3% (70.7% to 92.1%) | 91.2% (89.0% to 93.2%) |
| Any cat component | 83.6% (71.2% to 92.2%) | 90.7% (88.4% to 92.8%) |
| Fel d 1 | 83.6% (71.2% to 92.2%) | 91.4% (89.2% to 93.4%) |
| Fel d 2 | 38.2% (25.4% to 52.3%) | 97.5% (96.1% to 98.5%) |
| Fel d 4 | 16.4% (7.8% to 28.8%) | 99.2% (98.2% to 99.7%) |
| Dog extract | 78.3% (56.3% to 92.5%) | 90.4% (88.1% to 92.4%) |
| Any dog component | 75.0% (53.3% to 90.2%) | 93.9% (92.0% to 95.5%) |
| Can f 1 | 58.3% (36.6% to 77.9%) | 98.4% (97.2% to 99.2%) |
| Can f 2 | 16.7% (4.7% to 37.4%) | 99.5% (98.6% to 99.9%) |
| Can f 3 | 25.0% (9.8% to 46.7%) | 99.6% (98.8% to 99.9%) |
| Can f 5 | 50.0% (29.1% to 70.9%) | 95.2% (93.5% to 96.6%) |
| Can f 6 | 29.2% (12.6% to 51.1%) | 99.2% (98.3% to 99.7%) |
| 16 y | ||
| Cat extract | 80.5% (70.6% to 88.2%) | 87.9% (85.2% to 90.2%) |
| Any cat component | 79.3% (69.3% to 87.3%) | 85.4% (82.6% to 88.0%) |
| Fel d 1 | 75.9% (65.5% to 84.4%) | 86.7% (83.9% to 89.1%) |
| Fel d 2 | 29.9% (20.5% to 40.6%) | 95.8% (94.0% to 97.2%) |
| Fel d 4 | 23.0% (14.6% to 33.2%) | 97.4% (95.9% to 98.5%) |
| Dog extract | 76.7% (61.4% to 88.2%) | 80.3% (77.2% to 83.1%) |
| Any dog component | 65.1% (49.1% to 79.0%) | 88.2% (85.6% to 90.4%) |
| Can f 1 | 44.2% (29.1% to 60.1%) | 96.7% (95.2% to 97.9%) |
| Can f 2 | 9.3% (2.6% to 22.1%) | 99.2% (98.2% to 99.7%) |
| Can f 3 | 9.3% (2.6% to 22.1%) | 99.0% (98.1% to 99.6%) |
| Can f 5 | 53.5% (37.7% to 68.8%) | 89.8% (87.4% to 91.9%) |
| Can f 6 | 25.6% (13.5% to 41.2%) | 97.0% (95.5% to 98.1%) |
Value are shown as proportions (95% CIs).