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. Author manuscript; available in PMC: 2019 Jun 27.
Published in final edited form as: Allergy. 2015 Mar 22;70(6):638–652. doi: 10.1111/all.12592

Table 2. Heat map of IgE reactivities to peanut extract, peanut allergen components, plant profilins, and carbohydrate markers. Ranges of allergen-specific IgE levels are indicated.

Asymptomatic
Africa
peanut Profilins CCD ß-hexosaminidase
release in RBL assay
(allergen concentration
0.01 μg/ml) (%)



ImmunoCAP
Peanut IgE
rAra h 1 rAra h 2 rAra h 3 nAra h 6 rAra h 8 rAra h 9 rBet v 2 rHev b 8 rMer a 1 rPhl p 12 rPru du 4 rTri a 12 nCry j 1 nCyn d 1 nCup a 1 MUXF3 nPhl p 4
1 200.00 8.36 13.38 ≤0.35 7.87 ≤0.35 4.81 27.00 118.81 81.14 5.96 32.87 17.99 18.54 131.39 44.68 4.43 25.38   6.64
2 190.00 0.40 0.49 ≤0.35 ≤0.35 ≤0.35 12.38 23.02 106.53 114.28 40.42 110.21 108.89 30.02 134.79 88.01 4.65 38.98   3.64
3 79.00 ≤0.35 48.38 2.95 51.62 ≤0.35 ≤0.35 72.33 117.48 120.09 14.63 71.72 50.47 12.29 137.52 50.52 9.45 40.71   0.00
4 30.00 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.47 ≤0.35 2.10 0.78 ≤0.35 0.43 ≤0.35 0.65 130.98 34.30 3.05 13.06   0.00
5 28.00 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 6.75 36.56 18.21 ≤0.35 12.04 1.49 2.90 129.03 12.71 1.48 12.66   1.47
6 28.00 ≤0.35 19.84 2.70 13.30 ≤0.35 5.47 18.83 39.62 35.34 1.55 14.61 4.92 0.67 90.76 3.47 ≤0.35 1.88   1.84
7 18.60 0.43 3.08 ≤0.35 ≤0.35 ≤0.35 ≤0.35 19.38 70.24 51.07 3.55 39.27 14.55 22.32 91.35 43.04 ≤0.35 6.39   1.94
8 18.40 0.36 ≤0.35 ≤0.35 ≤0.35 ≤0.35 7.09 ≤0.35 1.47 ≤0.35 ≤0.35 ≤0.35 ≤0.35 9.31 133.26 31.59 0.89 17.16   3.11
9 17.00 0.45 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.25 ≤0.35 0.45 ≤0.35 ≤0.35 ≤0.35 ≤0.35 6.96 55.69 23.61 0.80 13.67   1.44
10 15.80 0.48 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.56 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 104.71 6.53 ≤0.35 12.38   2.15
11 13.80 13.00 0.82 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 4.01 23.85 10.78 ≤0.35 10.18   1.97
12 12.60 0.40 0.42 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   2.78
13 12.00 0.53 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.38 41.30 4.38 1.56 24.81   4.36
14 9.60 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.56 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.11 4.52 3.92 0.62 2.68   0.00
15 8.40 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 6.34 42.05 19.64 ≤0.35 20.36 10.34 ≤0.35 134.63 11.44 ≤0.35 1.30   3.28
16 7.00 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.47 ≤0.35 ≤0.35 ≤0.35 ≤0.35 8.74 21.17 36.88 1.51 9.55   1.43
17 5.80 ≤0.35 0.76 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 142.30 14.31 ≤0.35 ≤0.35   2.63
18 5.30 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 2.13 ≤0.35 ≤0.35 1.44   0.00
19 4.70 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.53 2.03 1.39 ≤0.35 0.51 ≤0.35 2.66 33.20 20.02 1.74 5.63   1.53
20 4.60 3.21 0.61 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.50 6.01 3.31 ≤0.35 1.03 2.25 0.52 99.98 1.82 ≤0.35 3.93   1.20
21 4.10 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.70 3.44 2.12 0.67 2.96   0.00
22 4.00 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.17 6.43 5.59 ≤0.35 1.96 ≤0.35 ≤0.35 63.69 15.57 0.63 2.42   0.00
23 4.00 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.78 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.28 93.82 16.88 1.55 3.88   1.24
24 3.80 1.24 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 2.84 ≤0.35 ≤0.35 1.57   2.14
25 3.70 1.02 0.48 ≤0.35 0.37 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 7.03 0.89 ≤0.35 3.62   0.00
26 3.40 0.53 ≤0.35 0.63 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.40 13.35 1.42 2.38 8.25   0.00
27 2.70 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 4.77 29.80 26.35 1.50 6.07   0.00
28 2.30 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 7.61 7.05 23.40 1.04 3.59   1.57
29 2.20 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 3.12 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   2.46
30 1.90 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 4.79 6.24 16.34 2.06 4.41   0.00
31 1.90 0.45 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.47 1.53 1.30 ≤0.35 1.13   1.80
32 1.66 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   1.12
33 1.40 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.58 4.11 0.66 0.61 3.12   0.71
34 1.24 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 6.05 133.86 16.78 ≤0.35 7.53   1.63
35 0.98 ≤0.35 0.36 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.48 ≤0.35 ≤0.35 0.43   1.92
36 0.88 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.60 1.90 1.41 ≤0.35 2.21   1.78
37 0.84 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.59 ≤0.35 ≤0.35 0.36   0.72
38 0.80 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 9.87 136.23 42.93 ≤0.35 3.03   0.98
39 0.78 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.88 19.73 5.94 0.37 1.05   0.00
40 0.69 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.22 2.23 1.23 ≤0.35 1.46   0.00
41 0.66 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.71 139.12 4.25 ≤0.35 4.73   2.15
42 0.56 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.08 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   0.75
43 0.50 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.36 76.11 24.11 ≤0.35 2.48   3.29
44 0.47 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.59 19.64 4.58 ≤0.35 0.67    n.d.
45 0.43 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.60 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 126.62 4.76 ≤0.35 2.39   1.97
46 0.42 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   2.93
47 0.42 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 75.80 4.19 ≤0.35 3.30   2.34
48 0.41 ≤0.35 0.69 ≤0.35 0.72 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.71 ≤0.35 ≤0.35 ≤0.35   0.00
49 0.36 0.65 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.43 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   4.44
50 0.30 ≤0.35 0.42 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   2.42
51 0.30 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.55 ≤0.35 ≤0.35   1.97
52 0.26 2.96 ≤0.35 ≤0.35 ≤0.35 1.86 1.66 1.30 3.52 2.36 1.04 3.93 ≤0.35 0.99 43.77 3.01 ≤0.35 2.05   1.34
53 0.20 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.37 ≤0.35 0.71 ≤0.35 ≤0.35   4.45
54 0.10 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.63 4.65 3.15 ≤0.35 3.98   2.34
Median 2.50 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.62 20.45 4.22 ≤0.35 2.82   1.63
Upper quartile 10.20 0.40 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.82 ≤0.35 ≤0.35 ≤0.35 ≤0.35 3.18 101.20 17.67 0.93 6.68   2.34
Lower quartile 0.64 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.81 0.63 ≤0.35 0.61   0.71
55 1300 26.31 22.65 2.28 14.4 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.56 1.04 0.9 ≤0.35 1.94 11.39
56 770 49.95 40.51 2.72 11.14 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.52 20.86
57 660 100.5 40.23 5.09 28.87   5.37 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 2.99 0.46 7.45 ≤0.35 1.64 13.34
58 420 8.99 1.43 0.63 6.13 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 16.70
59 400 20.71 6.16 0.78 9.94 ≤0.35 ≤0.35 ≤0.35 0.43 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.46 0.47 0.94 ≤0.35 2.14 9.93
60 400 19.37 4.68 4.15 9.12 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 17.60
61 380 72.71 13.63 7.6 12.46 12.91 ≤0.35 2.71 16.29 10.07 1.49 13.58 1.87 ≤0.35 1.33 ≤0.35 ≤0.35 9.18 16.68
62 380 35.31 23.21 5.36 17.05 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.38 ≤0.35 ≤0.35 0.62 19.18
63 370 65.8 28.21 3.02 9.51 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 4.92 ≤0.35 ≤0.35 ≤0.35 10.80
64 350 2.68 1.99 4.49 14.51 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.44 ≤0.35 ≤0.35 ≤0.35   2.09
65 320 3.81 9.18 1.98 4.61 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 23.59
66 300 23.04 8.54 4.2 7.9 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 15.26
67 280 34.02 21.36 1.45 17.75 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 10.35
68 270 58.84 9.12 4.69 15.36 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 18.37
69 250 38.11 15.44 ≤0.35 6.41 0.42 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 22.36 0.78 ≤0.35 ≤0.35   4.04
70 140 51.64 10.09 ≤0.35 8.04 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 4.12 ≤0.35 ≤0.35 2.85 14.96
71 98 34.03 7.73 0.63 2.06 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.68 2.88 2.78 ≤0.35 1.35   7.93
72 98 30.1 4.87 0.69 2.36 ≤0.35 ≤0.35 0.53 3.81 2.49 0.54 2.62 0.81 ≤0.35   0.57 ≤0.35 ≤0.35 ≤0.35   9.29
73 95 13.23 1.72 0.59 2.48 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.74 ≤0.35 ≤0.35 ≤0.35   7.41
74 75 9.79 2.91 1.34 4.39 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.81 ≤0.35 ≤0.35 ≤0.35   4.50
75 71 15.66 4.43 2.31 7.66 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.32 ≤0.35 ≤0.35 0.92 13.30
76 71 10.82 10.51 10.56 2.62 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 10.47
77 67 8.8 25.48 0.75 25.03 1.43 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   8.32
78 60 67.55 9.75 4.59 14.38 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 4.9 ≤0.35 ≤0.35 ≤0.35 13.77
79 28 2.39 0.61 ≤0.35 2.41 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 5.14   1.63
Median 280 26.31 9.18 2.28 9.12 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 0.46 ≤0.35 ≤0.35 ≤0.35 11.39
Upper quartile 390 50.8 22.01 4.54 14.46 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 1.57 ≤0.35 ≤0.35 1.5 16.69
Lower quartile 85 10.31 4.55 0.66 4.5 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35 ≤0.35   8.13
ImmunoCAP (kUA/l) ≤0.35 Allergen-specfic IgE levels ISAC (ISU-E) ≤0.35 Mediator release in RBL-assay (%) 0–5
0.35–1 >0.35–1 5–10
1–15 1–15 >10
>15 >15