FIG 3.
Amino acid sequence alignment of APRTh and APRT. Tt27APRTh, APRTh from T. thermophilus HB27; TO73_0477, APRTh from T. aquaticus; Ocepr_0780, APRTh from Oceanithermus profundus; Deide13870, APRTh from Deinococcus deserti; SU48_05320, APRTh from Deinococcus puniceus. Tt27APRT, APRT from T. thermophilus HB27; TO73_0476, APRT from T. aquaticus; Ocepr_0779, APRT from Oceanithermus profundus; Deide13880, APRT from Deinococcus deserti; SU48_05315, APRT from Deinococcus puniceus. ScAPRT, APRT from S. cerevisiae. Black boxes at the bottom indicate the residues demonstrated to play important roles in the catalytic reaction of ScAPRT. The corresponding residues in the related proteins are boxed with bold lines.