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. 2019 Jun 7;22(2):237–247. doi: 10.4048/jbc.2019.22.e29

Figure 3. Induction of cell apoptosis and cell cycle arrest in Tam-resistant BC cells by CDCA8 knockdown. MCF-7/TR-shCtrl, MCF-7/TR-shCDCA8-1, MCF-7/TR-shCDCA8-2, T47D/TR-shCtrl, T47D/TR-shCDCA8-1, and T47D/TR-shCDCA8-2 cells were cultured with or without 4OH-Tam. Total cells were collected and subjected to apoptosis (A, B) and cell cycle (C, D) analysis. Data represent mean ± standard deviation from three independent experiments with each measured in triplicate.

Figure 3

BC = breast cancer; CDCA8 = cell division cycle associated 8; shCtrl = shRNA control; shCDCA8 = shRNA targeting CDCA8; Tam = tamoxifen; FITC = fluorescein isothiocyanate.

*p < 0.01.