Table 3. Cox hazard regression analysis for the primary endpoint.
| Variables | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| Age | 1.022 (1.019–1.026) | <0.001 | 1.017 (1.013–1.022) | <0.001 | |
| Male | 0.905 (0.830–0.987) | 0.024 | 1.007 (0.906–1.118) | 0.902 | |
| BMI (kg/m2) | 0.958 (0.947–0.970) | <0.001 | 0.983 (0.970–0.997) | 0.018 | |
| De novo HF | 0.599 (0.548–0.654) | <0.001 | 0.755 (0.681–0.838) | <0.001 | |
| Ischemic HF | 1.297 (1.189–1.416) | <0.001 | 1.110 (0.996–1.236) | 0.058 | |
| LVEF (%) | 0.997 (0.994–1.000) | 0.029 | 0.994 (0.990–0.997) | 0.001 | |
| Hypertension | 1.356 (1.238–1.484) | <0.001 | 1.126 (1.009–1.257) | 0.034 | |
| DM | 1.366 (1.251–1.492) | <0.001 | 1.142 (1.028–1.268) | 0.013 | |
| AF | 1.233 (1.124–1.353) | <0.001 | 1.114 (0.995–1.247) | 0.060 | |
| Hb (g/dL) | 0.885 (0.869–0.902) | <0.001 | 0.932 (0.909–0.955) | <0.001 | |
| Cr (mg/dL) | 1.079 (1.056–1.103) | <0.001 | 1.056 (1.023–1.090) | 0.001 | |
| HsCRP (mg/dL) | 1.019 (1.009–1.029) | <0.001 | 1.011 (1.000–1.022) | 0.055 | |
| Narrow QRS (<120 ms) | 1 (Reference) | NA | 1 (Reference) | NA | |
| RBBB | 1.237 (1.051–1.454) | 0.010 | 1.103 (0.915–1.329) | 0.304 | |
| LBBB | 1.534 (1.295–1.816) | <0.001 | 1.392 (1.152–1.681) | 0.001 | |
| NICD | 1.454 (1.250–1.692) | <0.001 | 1.278 (1.074–1.520) | 0.006 | |
| ACEi or ARB | 0.772 (0.704–0.846) | <0.001 | 0.829 (0.746–0.922) | 0.001 | |
| BB | 0.699 (0.641–0.763) | <0.001 | 0.777 (0.704–0.857) | <0.001 | |
| MRA | 0.981 (0.899–1.070) | 0.660 | 1.078 (0.976–1.191) | 0.139 | |
ACEi = angiotensin-converting enzyme inhibitor; AF = atrial fibrillation; ARB = angiotensin II receptor blocker; BB = beta blocker; BMI = body mass index; CI = confidence interval; Cr = creatinine; DM = diabetes mellitus; Hb = hemoglobin; HF = heart failure; HR = hazard ratio; HsCRP = high-sensitivity C-reactive protein; LBBB = left bundle branch block; LVEF = left ventricular ejection fraction; MRA = mineralocorticoid receptor antagonist; NA = not applicable; NICD = nonspecific intraventricular conduction delay; RBBB = right bundle branch block.