Fig. 1. FAM83H over-expression is associated with poor prognosis of CC. (A) FAM83H expression at mRNA level in CC tissues in TCGA database. (B) FAM83H expression at mRNA level in CC tissues in GEPIA database (match TCGA normal data). (C) FAM83H expression at mRNA level in CC tissues in GEPIA database (match TCGA normal and GTEx data). (D) Real-time Quantitative Reverse Transcription PCR used to measure the expression level of FAM83H in human CC cell lines (SiHa and HeLa). The expression of FAM83H was significantly higher in CC cells relative to control cells. (E) Kaplan-Meier curves of OS of CC patients in TCGA database. Patients were sub-grouped into high (n=152) or low (n=152) groups based on the median of FAM83H expression. p=0.027. (F) Kaplan-Meier curves of OS of CC patients in GEPIA database. Patients were sub-grouped into high (n=146) or low (n=146) groups based on the median of FAM83H expression. (G) Kaplan-Meier curves of OS of CC patients in the Human Protein Atlas database. Patients were sub-grouped into high (n=224) or low (n=67) groups based on best cut-off point (p=0.004). ^*p<0.05, ^**p<0.01. FAM83H, family with sequence similarity 83 member H; CC, cervical cancer; TCGA, The Cancer Genome Atlas; GEPIA, Gene Expression Profiling Interactive Analysis; OS, overall survival; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; TPM, transcripts per million; HR, hazard ratio.