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. 2019 Jun 27;9:9335. doi: 10.1038/s41598-019-45860-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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B cell deficient µMT mice failed to expand the pool of splenic and uterine Treg cells as wild type (WT) controls did. (a) The number of B220+ splenic B cells remained stable in WT mice at midgestation compared to naïve mice. (b) In uterine tissue, the number of B cells increased in WT mice that were pregnant at gd10 when compared to naïve WT animals. In µMT mice, the frequency of B cells was, as expected, almost undetectable and this did not change upon pregnancy neither in spleen nor in uterus. Representative plots are shown in (c). (d,e) The number of regulatory T cells (Treg) was increased in pregnant WT mice at gd10 in spleen (c) and uterus (d) when compared to non-pregnant control females, while the Treg levels remained unaltered in pregnant µMT mice when compared to non-pregnant µMT mice (d,e). (f) Shows representative plots. (g) The number of splenic Treg cells correlated with the number of B220+ B cells in both WT and µMT mice. Data are analyzed using Kruskal-Wallis test and Mann-Whitney test and shown as median. n = 4–6 mice/group; *p < 0.05; **p < 0.01.