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. 2019 Jun 27;9:9324. doi: 10.1038/s41598-019-45796-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of the number of neurons responded with firing rate increase, decrease or no response to the microiontophoretic application of the given test compound. Hash symbols indicate effects occurred with significantly higher probability then the opposite effect (i.e., firing rate increase or decrease) according to binomial test: ^###p < 0.001.