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. 2019 Jun 27;9:9324. doi: 10.1038/s41598-019-45796-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of the type of interaction between NMDA and different test compounds. Data points and error bars represent mean and SEM, respectively. Sample sizes were 71, 39, 8 and 29 for PHA-543613, NS-1738, PNU-120596 and MLA, respectively. Hash symbols indicate significant difference between the summarized effect of NMDA and the given test compound during their sole administration [(NMDA − Sp) + (Sp_Drug − Sp)] and their combined effect during their co-application (NMDA_Drug − Sp) according to Wilcoxon signed rank test: ^###p < 0.001.