Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 27;9:9324. doi: 10.1038/s41598-019-45796-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Comparison of the effects of alpha7 nAChR agonist PHA-543613 and PAM NS-1738 during their separate and simultaneous application. Firing rate histograms show typical examples of neurons that responded with firing rate increase (A) or with firing rate decrease (B) to the microiontophoretic application of PHA-543613. Insets show typical extracellular action potentials of CA1 hippocampal pyramidal cells recorded in the given experimental session. Bar charts (mean ± SEM) assess the effects of PHA-543613, NS-1738 and their co-application on the spontaneous (C, N = 20) and NMDA-evoked (D, N = 19) firing rate. Asterisks indicate significant effects of the given compound compared with the baseline firing rate value according to Wilcoxon signed rank test: *p < 0.05, **p < 0.01, ***p < 0.001.