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. 2019 Jun 27;10:2816. doi: 10.1038/s41467-019-10687-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Screening results and prioritization considerations. Confirmed anticryptosporidial screening hits, lowest EC₅₀, and prioritization considerations for four benzoxaborole chemical scaffolds are shown. The 6-carboxamide antitrypanosomal chemical scaffold was prioritized for further study based on a large number of available analogs, existing safety data from a human African trypanosomiasis (HAT) drug development program, and the results of a preliminary murine efficacy study