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. 2019 Jun 27;9:9315. doi: 10.1038/s41598-019-45724-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alteration of metabolic and immunological parameters in P2rx7^−/− mice. (a) Body weight, (b) WAT weight, (c) blood glucose, (d) % of Tfh cells in PPs, (e) % of GC B cells in PPs, (f) % of faecal IgA-coated bacteria in P2rx7^−/− (yellow) and WT (blue) mice. Box plots are defined by the 25th and 75th percentiles. Centre line represents the median (50th percentile). Whiskers are defined as 1.5 times the interquartile range from the 25th or 75th percentiles. (g) Dynamic pattern of respiratory exchange ratio (RER) and relative mean RER values during the light and dark phase in WT and P2rx7^−/− mice (the displayed experiment is representative of three). *p < 0.05, **p < 0.01, ***p < 0.001, **** p < 0.0001, Wilcoxon rank-sum test; n = 10 per group.