Figure 3.

The lack of P2X7 receptor alters the gut microbiota at different taxonomic levels. (a,b) Log₁₀ of LDA scores for the most discriminant bacterial taxa identified by LEfSe in the IgA⁺ (a) and IgA⁻ (b) fractions of faecal microbiota from P2rx7^−/− and WT mice. Positive and negative LDA scores indicate the taxa enriched or depleted in P2rx7^−/− mice. Only taxa having a p < 0.05 (Wilcoxon rank-sum test) and LDA > |2.0| are shown. (c) Enrichment of indicated taxa (with relative abundance >0.1%) in the IgA⁺ and IgA⁻ fractions of P2rx7^−/− mice and WT littermate controls. Error bars indicate the standard error.