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. 2019 Jun 27;9:9364. doi: 10.1038/s41598-019-45170-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The power output spectra of (a) LolB^HIGH and (b) LolB^LOW mice exhibiting tremors compared to (c) Control and (d) Control^VEH mice. The tremor was defined by the AUC of tremor frequency bandwidth divided by AUC of overall motion power [100* (10–30 Hz power)/(0–45 Hz power)]. This ratio is expressed as motion power percentage (MPP) and in untreated mice; the MPP is approximately 40 to 55%, corresponding not to any visible tremor but to normal motion within these bandwidths.