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. 2019 Jun 27;9:9364. doi: 10.1038/s41598-019-45170-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lolitrem B intoxicated mice exhibit a dose-dependent tremor (a1) and latency to falling (a2) over 24 h time. Significant tremor and impaired motor coordination was measured for LolB^LOW (n = 8) and LolB^HIGH (n = 6) compared to Control^VEH (n = 7). Terpendole C intoxicated mice monitored show a dose-dependent tremor (b1) and latency to falling (b2) over 2 h. Significant tremor and impaired motor coordination was measured for TerpC^LOW (n = 8) and TerpC^HIGH (n = 8) compared to Control^VEH (n = 7). No significant tremor or motor impairment was found in the Control (n = 8) animals. All data are mean ± S.E.M. P values determined by two-way ANOVA by uncorrected Fisher’s LSD post-test for multigroup comparison against vehicle control. High dose: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; low dose: ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001.