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. 2019 Jun 27;9:9364. doi: 10.1038/s41598-019-45170-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lolitrem B concentrations in lipophilic extracts of tissues harvested at 6 h and 24 h post treatment (a) showing lolitrem B accumulation over time, in the cerebral cortex: LolB^HIGH [(6 h, n = 6), (24 h, n = 8)] and LolB^LOW [(6 h, n = 3), (24 h, n = 4)] as well as the thalamus: LolB^HIGH [(6 h, n = 7), (24 h, n = 6)] and LolB^LOW [(6 h, n = 3), (24 h, n = 7)]. Lolitrem B was below the detection limit in the cerebellum and brainstem regions. Graph (b) shows elimination of lolitrem B over time from the kidney: LolB^HIGH [(6 h, n = 7), (24 h, n = 8)] and LolB^LOW [(6 h, n = 7), (24 h, n = 8)], as well as from the liver: LolB^HIGH [(6 h, n = 7), (24 h, n = 8)] and LolB^LOW [(6 h, n = 8), (24 h, n = 8)]. All data are mean ± S.E.M.