Table 1.
The mean concentration of lolitrem B (pg/mg of tissue) in body and brain tissues of mice exposed to LolBHIGH and LolBLOW at 6 h and 24 h post treatment.
| Group | Kidney | Liver | Cerebral cortex | Thalamus | Brainstem | Cerebellum |
|---|---|---|---|---|---|---|
| LolBHIGH (6 h) | 1084.4 ± 171.0 (n = 7) | 201.5 ± 32.7 (n = 7) | 13.2 ± 2.2 (n = 7) | 8.8 ± 1.4 (n = 6) | ND | ND |
| LolBHIGH (24 h) | 752.0 ± 171.8 (n = 8) | 76.7 ± 11.2 (n = 8) | 16.0 ± 2.8 (n = 8) | 12.9 ± 3.4 (n = 6) | ND | ND |
| LolBLOW (6 h) | 162.0 ± 50.7 n = 8) | 53.6 ± 10.9 (n = 8) | 7.4 ± 3.3 (n = 3)* | 8.1 ± 2.5 (n = 3)* | ND | ND |
| LolBLOW (24 h) | 107.2 ± 41.4 (n = 8) | 23.1 ± 7.5 (n = 5)* | 10.1 ± 1.9 (n = 4)* | 8.3 ± 1.4 (n = 7)* | ND | ND |
*Some replicates in the LolBLOW cohorts were found to contain below LoD (0.8 ng/mL levels of lolitrem B. ND-Not detected.