Table 1.
Patient, graft and surgical features in the whole and matched cohorts.
| Whole cohort | Matched cohort | |||||
|---|---|---|---|---|---|---|
| SCS (n = 269) |
HOPE (n = 25) |
p* | SCS (n = 50) |
HOPE (n = 25) | p* | |
| Recipient features | ||||||
| Age (y) | 55.3 (8.7) | 56.3 (9) | 0.60 | 55.9 (7.4) | 56.3 (9) | 0.85 |
| Sex (male) | 200 (74.3%) | 15 (60.0%) | 0.19 | 37 (74.0%) | 15 (60.0%) | 0.33 |
| BMI (Kg/m2) | 25.2 (3.7) | 25 (3.3) | 0.74 | 26.2 (4.6) | 25 (3.3) | 0.24 |
| MELD | 14.3 (7.3) | 15.3 (8.6) | 0.52 | 15.5 (8.5) | 15.3 (8.6) | 0.93 |
| Creatinine at LT (mg/dl) | 1.08 (1.05) | 0.96 (0.39) | 0.59 | 0.94 (0.46) | 0.96 (0.39) | 0.79 |
| RRT at LT | 13 (4.8%) | 1 (4.0%) | 1.00 | 3 (6.0%) | 1 (4.0%) | 1.00 |
| Previous major abdominal surgery | 82 (30.5%) | 11 (44.0%) | 0.25 | 13 (26.0%) | 11 (44.0%) | 0.19 |
| Life support | 5 (1.9%) | 1 (4.0%) | 1.00 | 1 (2.0%) | 1 (4.0%) | 1.00 |
| Ascites at LT | 99 (36.8%) | 8 (32.0%) | 0.77 | 20 (40.0%) | 8 (32.0%) | 0.67 |
| History of portal vein thrombosis | 22 (8.2%) | 3 (12.0%) | 0.79 | 4 (8.0%) | 3 (12.0%) | 0.89 |
| HCC | 147 (54.6%) | 17 (68.0%) | 0.28 | 28 (56.0%) | 17 (68.0%) | 0.45 |
| Donor features | ||||||
| Age (y) | 60.9 (18.4) | 74.3 (10.9) | <0.001 | 74.9 (10.3) | 74.3 (10.9) | 0.81 |
| BMI (Kg/m2) | 25.5 (4.5) | 26.7 (3.9) | 0.19 | 26.1 (3.8) | 26.7 (3.9) | 0.51 |
| Macrosteatosis (%) | 4.7 (8.4) | 7.4 (10.1) | 0.14 | 6.3 (8.9) | 7.4 (10.1) | 0.66 |
| Macrosteatosis ≥15% | 34 (12.6%) | 5 (20.0%) | 0.54 | 10 (20.0%) | 5 (20.0%) | 1.00 |
| Graft weight (gr) | 1527 (364) | 1432 (346) | 0.21 | 1431 (290) | 1432 (346) | 0.99 |
| Matching and prognostic scores | ||||||
| D-MELD | 850 (442) | 1110 (583) | 0.007 | 1118 (481) | 1110 (583) | 0.95 |
| BAR | 8.7 (7.6) | 10 (8) | 0.44 | 9.8 (7.9) | 10 (8) | 0.94 |
| DRI | 1.78 (0.51) | 2.09 (0.52) | 0.004 | 2.15 (0.42) | 2.09 (0.52) | 0.64 |
| GRBWR (%) | 2.15 (0.52) | 1.95 (0.42) | 0.07 | 1.98 (0.43) | 1.95 (0.42) | 0.80 |
| Preservation and operation details | ||||||
| Total preservation time (min) | 393 (82) | 499 (59) | <0.001 | 391 (72) | 499 (59) | <0.001 |
| Cold ischemia time (min) | 393 (82) | 311 (53) | <0.001 | 391 (72) | 311 (53) | <0.001 |
| Perfusion time (min) | na | 186 (49) | na | 186 (49) | ||
| Rec. warm ischemia time (min) | 24 (8) | 23 (7) | 0.52 | 24 (5) | 23 (7) | 0.65 |
| Packed red blood cells units | 7.3 (11.3) | 5.2 (5.8) | 0.35 | 8.4 (12.7) | 5.2 (5.8) | 0.23 |
| Plasma (mL) | 2167 (2750) | 1680 (1864) | 0.386 | 2317 (2749) | 1680 (1864) | 0.30 |
| Colloids (mL) | 1390 (979) | 1756 (3409) | 0.20 | 1428 (949) | 1756 (3409) | 0.53 |
| Crystalloids (mL) | 7242 (3621) | 6930 (3724) | 0.68 | 6848 (3127) | 6930 (3724) | 0.92 |
Data are expressed as mean (standard deviation) or number (percentage). *p-value referring to Mann-Whitney, Chi-square or Fisher’s test, as appropriate. Abbreviations: SCS, static cold storage; HOPE, hypothermic oxygenated machine perfusion; y, years; BMI, body mass index; MELD, model for end-stage liver disease; LT, liver transplant; RRT, renal replacement therapy; HCC, hepatocellular carcinoma; D-MELD, donor age * MELD; BAR, balance of risk score; DRI, donor risk index score; GRBWR, graft-to-recipient body weight ratio.