Table 1.

Overview of in vitro and in vivo evaluation of PET radiotracers for GPR44

Assay		Species	Model	11C-AZ12204657	11C-MK7246
In vitro cell binding	Islet	Human	Healthy	High, receptor-specific	N/A
	Exocrine			Low, non-specific	N/A
In vitro autoradiography	Pancreas	Pig	Healthy	Pancreatic binding receptor-specific	N/A
			STZ T1D	No binding in pancreas	N/A
		Non-human primate		Pancreatic binding receptor-specific	N/A
		Human	Healthy	Binding in islets, receptor-specific	Binding in islets, receptor-specific
			T2D	Binding in islets, receptor-specific	N/A
			T1D	No binding in pancreas	N/A
In vivo targeting in mouse	Transplanted islets	Human	Healthy	Binding to islets, receptor-specific	N/A
In vivo targeting	Pancreas	Pig	Healthy	Receptor-specific	Receptor-specific
		Non-human primate	Healthy	Receptor-specific	N/A