Fig. 2.

Highest reported value for each terpenoid class produced by different microbial hosts. Color intensity correlates to produced amounts for each class. Mode of cultivation: shake flask (sf), bioreactor (br), microtiter plate (mtp). If no cultivation mode is stated, details were not elaborated in literature, or the values could not be clearly assigned to one of the three modes of cultivation. Since titers and yields cannot easily be correlated due to considerable variations in growth and cell densities of different species and engineered strains, values were taken as stated in literature, preferably as titer (mg L⁻¹ or g L⁻¹), otherwise as space time yield (mg L⁻¹ d⁻¹) or specific yield (mg g⁻¹ dry cell weight (DCW)). Superscript numbers behind the terpenoid molecule refer to footnotes with additional information on production time frame and eventually specific yield or space time yield, if available. Values that resulted from our own calculations based on available data in the respective study are given in italics. Asterisk indicates that this work has been substantially challenged by other authors (see Bian et al. 2018). ¹Induction for 2 days; cultivation in 14 mL [sic!] Falcon tubes; ²induction for 52 h; specific yield 20.4 μg g⁻¹ DCW; ³cultivation for 142 h; maximum space time yield 18 mg L⁻¹d⁻¹; specific yield 2 mg g⁻¹ DCW; ⁴cultivation for 7 days; specific yield 17 mg g⁻¹ DCW; maximum space time yield 0.08 mg L⁻¹ h⁻¹; ⁵12 h of growth and 24 h of induction; maximum specific productivity 0.018 g h⁻¹ g⁻¹ DCW; ⁶cultivation rounds lasted between 120 and 160 h; ⁷cultivation lasted close to 2 days including 20 h of induction; ⁸induction for 48 h; ⁹after 104 h of induction; average space time yield 14.6 mg L⁻¹ h⁻¹; specific yield 55 mg g⁻¹ DCW; ¹⁰growth for 24 h and induction for 48 h; ¹¹48 h of induction; ¹²cultivation for 72 h; ¹³cultivation for 168 h; specific yield 10.32 mg g⁻¹ DCW; ¹⁴cultivation for 110 h; specific yield 16.7 mg g⁻¹ DCW; ¹⁵cultivation for 72 h; ¹⁶cultivation for 9 days; ¹⁷cultivation for 5 days; ¹⁸cultivation for 96 h; highest rate 50 μg L⁻¹ h⁻¹; ¹⁹cultivation for 10 days; specific productivity over a 48 h culture 0.492 mg L⁻¹OD₇₃₀⁻¹; ²⁰cultivation for 48 h;²¹ cultivation for 1 week; specific yield 3.7 μg g⁻¹ DCW; ²²2 days of cultivation; specific yield 0.98 mg g⁻¹ DCW; ²³specific yield 2.06 mg g⁻¹ DCW; specific titer 0.92 mg L⁻¹OD⁻¹; ²⁴induction for 108 h; ²⁵cultivation for 60 h; ²⁶induction for 74 h; ²⁷cultivation for 39.5 h; specific yield 4.6 mg g⁻¹ DCW; ²⁸after 130 h of cultivation; ²⁹after 2 weeks; maximum space time yield 2.24 g L⁻¹ h⁻¹; ³⁰206 h of cultivation; specific yield 70.9 mg g⁻¹ DCW; ³¹144 h of fermentation; specific yield 76.9 mg g⁻¹ DCW; ³²cultivation for 48 h; ³³cultivation for 3 days; specific yield 1.36 mg g⁻¹ DCW; ³⁴cultivation for 120 h; specific yield 33.98 mg g⁻¹ DCW; ³⁵cultivation for 122 h; specific yield 90 mg g⁻¹ DCW