Table II.
Model Parameter Estimates for the Midazolam PK Model and the Bootstrap Results Based on n = 250 Resampling
| Parameter | Model estimate (RSE) | Bootstrap median (90 CI) | |
|---|---|---|---|
|
Midazolam clearance† CLi = CL30.2 kg × (WTi/30.2)k1 |
(CL/F)30.2 kg (L/h) | 102.6 (9%) | 101.4 (89.1–118.2) |
| k1 | 0.874 (13%) | 0.901 (0.698–1.11) | |
|
Volume of distribution† Vc,i = Vc,30.2 kg × (WTi/30.2)k2 |
(Vc/F)30.2 kg (L) | 156 (25%) | 141 (76.5–210) |
| k2 | 1.88 (17%) | 2.15 (1.43–3.30) | |
|
Peripheral volume† Vp,i = Vp,30.2 kg × (WTi/30.2)k3 |
(Vp/F)30.2 kg (L) | 255 (14%) | 252 (197–338) |
| k3 | 0.91 (23%) | 0.88 (0.60–1.21) | |
|
Intercompartmental clearance† Qi = Q30.2 kg × (WTi/30.2)k4 |
(Q/F)30.2 kg (L/h) | 121.8 (21%) | 115.6 (73.7–163) |
| k4 | 0.75 fix | 0.75 fix | |
| Absorption rate constant | ka (h−1) | 3.5 fix | 3.5 fix |
| IIV clearance | ω2 CL/F | 0.158 (41%) | 0.145 (0.063–0.259) |
| IIV volume of distribution | ω2 Vc/F | 1.19 (27%) | 1.06 (0.64–1.71) |
| Proportional error | σ 2 | 0.283 (13%) | 0.272 (0.222–0.346) |
RSE is the relative standard error, and 90 CI is the 90% confidence interval representing the 5th and 95th percentiles. Interindividual and residual variability values are shown as variance estimates
†Parameters are apparent parameters, as only oral data was included