Table IV.

Prediction error (PE) of scaled clearance values using the pediatric covariate function for CYP3A-mediated midazolam clearance versus reported pediatric clearance values for three representative pediatric subjects of 10, 20, and 50 kg (Eq. 4), with negative and positive values for under- and overpredicted clearance values, respectively

	Infant (10 kg)	Child (20 kg)	Adolescent (50 kg)
Atorvastatin	− 26.7%	− 20.1%	− 10.5%
Quinidine	− 33.5%	− 39.0%	− 12.8%
Sildenafil	20.7%	10.6%	− 1.4%
Sirolimus	NA	− 58.3%	− 31.5%
Sufentanil	− 10.3%	− 12.0%	1.1%
Tacrolimus	− 44.6%	− 39.6%	− 32.3%
Tamsulosin	NA	8.1%	21.2%
Vincristine	− 64.3%	NA	NA

NA denotes no pediatric or adult clearance values reported in literature

Colors indicate an accurate prediction (absolute PE < 30%, bold), a reasonably accurate prediction (absolute PE 30–50%, bold italics), and an inaccurate prediction (absolute PE ≥ 50%, italics)