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. 2019 Jun 25;9(6):e029189. doi: 10.1136/bmjopen-2019-029189

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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A visual representation of the CONFOCAL2 study design from enrolment to 3 and 12 months follow-up assessments. APACHE II, Acute Physiology and Chronic Health Evaluation II; Hb, haemoglobin; ICU, intensive care unit; NIRS, near-infrared spectroscopy; pCO₂, partial arterial pressure of carbon dioxide; pO₂, partial arterial pressure of oxygen; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status.