Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 27;10:2819. doi: 10.1038/s41467-019-10800-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — vHipp-NAc and vHipp-mPFC pathways differentially affect distinct types of cognitive flexibility. MAM treatment causes a deficit in both reversal learning and in extradimensional set-shifting. Inhibition of the vHipp-NAc pathway completely abolishes the MAM-induced deficit in reversal learning (a). Asterisk is significantly different than saline/GFP. Plus is significantly different than MAM/GFP. However, vHipp-NAc inhibition had no effect on extradimensional set-shifting (c). Asterisk is significant main effect of MAM. n = 6–7 rats per group. Conversely, inhibition of the vHipp-mPFC pathway had no effect on reversal learning performance (b) Asterisk is significant main effect of MAM. n = 6–9 rats per group. However, vHipp-mPFC inhibition did attenuate the MAM-induced deficit in extradimensional set-shifting (d). Aserisk is significantly different than saline/GFP; plus is significantly different than MAM/GFP. n = 6–7 rats per group. All stages of the AST are shown in e, (f). All data were analyzed using Two-Way ANOVA and Holm–Sidak tests. Data are shown as mean ± SEM