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. 2019 Jun 26;9(6):180263. doi: 10.1098/rsob.180263

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 8. — Illustration of MARK2-mediated recognition of actin status and regulation of spindle position. Cortical MARK2 and dynein occupy outer and inner cortical areas, in alignment with their distinct roles in spindle centring and pulling, respectively. MARK2 recognizes actin status in interphase (a), and actin perturbation-induced spindle off-centring can be corrected by MARK2 (b). To enable spindle centring, we propose that MARK2 at the cortical membrane can selectively act on astral microtubule ends that reach retraction fibres.