Table 3.

Parameters of patients 2, 16 and 23 derived by the optimization model (2.5) with at most data from the first five visits and closed-form FT4 estimations based on formula (2.2).

patient S/N	visit times	A	IC50	C	C1	FT4 formula
2	9	0.052	58.151	0.003	−0.051	$\tilde{y}(t,d)={\displaystyle \frac{3.024/(58.151+d){\mathrm{e}}^{3.024t/(58.151+d)}}{0.003{\mathrm{e}}^{3.024t/(58.151+d)}-0.154/(58.151+d)}}$
16	3	5.194	72.901	0.371	−0.001	$\tilde{y}(t,d)={\displaystyle \frac{378.648/(72.901+d){\mathrm{e}}^{378.648t/(72.901+d)}}{0.371{\mathrm{e}}^{378.648t/(72.901+d)}-0.379/(72.901+d)}}$
23	4	4.237	35.062	0.246	−0.033	$\tilde{y}(t,d)={\displaystyle \frac{148.558/(35.062+d){\mathrm{e}}^{148.558t/(35.062+d)}}{0.246{\mathrm{e}}^{148.558t/(35.062+d)}-4.902/(35.062+d)}}$