Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 19;16(155):20190244. doi: 10.1098/rsif.2019.0244

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

PMC Copyright notice

Figure 13. — The inchworm translocation cycle of HCV helicase. Following ATP binding, the left motor domain (orange) moves towards the right motor domain (blue), so that the protein conformation is changed from (a) the open to (b) the closed one. In the closed conformation, hydrolysis occurs and its products are released (c), inducing the return (d) to the initial open conformation. Within the cycle, interactions between the motor domains and the DNA strand (green) are switched. When ATP binds, a link (red) between the right domain and the strand is established, so that this domain holds the DNA. After the hydrolysis, the reconnection occurs (c) and now the left domain grasps the DNA. As a result, the motor translocates itself by one DNA base in the right direction after each cycle. Adapted from [29]. See also the electronic supplementary material, video S6. (Online version in colour.)