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USP9X in Wnt/β-catenin signaling and breast carcinogenesis. The protein deubiquitinase USP9X interacts with BCL9 and acts to remove Lys-63–linked polyubiquitin on lysine 212 of BCL9. Then, USP9X-targeted BCL9 deubiquitination facilitates the formation of the β-catenin/BCL9/PYGO complex, thereby potentiating the transcriptional activation of Wnt/β-catenin target genes and promoting the proliferation and invasion of breast cancer cells.
