Table 1.
Genes/proteins used in this study
| Gene | Function |
|---|---|
| ASF1 | Nucleosome assembly factor and histone chaperone |
| CHK1 | Effector kinase in DNA damage checkpoint |
| CIT1 | Citrate synthase, the first enzyme of the TCA cycle |
| COX1 | Subunit of cytochrome c oxidase, enzyme of the ETC |
| CRT1 | Transcriptional repressor of DNA damage–regulated genes |
| CYC1 | Cytochrome c (isoform 1); component of the ETC |
| CYT1 | Cytochrome c1, component of the ETC |
| DUN1 | Protein kinase involved in DDR; functions downstream of Rad53 |
| HAP1 | Transcription factor regulated by heme; regulates expression of respiratory genes |
| HAP4 | Subunit of the Hap2/3/4/5 transcription complex; regulator of respiratory genes |
| HIR1 | Subunit of the HIR complex; involved in regulation of histone gene transcription |
| HHF1 | Histone H4; one of two identical histone H4 proteins |
| HHF2 | Histone H4; one of two identical histone H4 proteins |
| HHT1 | Histone H3; one of two identical histone H3 proteins |
| HHT2 | Histone H3; one of two identical histone H3 proteins |
| HTA1 | Histone H2A; one of two nearly identical H2A proteins |
| HTA2 | Histone H2A; one of two nearly identical H2A proteins |
| HTB1 | Histone H2B; one of two nearly identical H2B proteins |
| HTB2 | Histone H2B; one of two nearly identical H2B proteins |
| IDH1 | Subunit of isocitrate dehydrogenase; enzyme of the TCA cycle |
| MBP1 | Transcription factor; with Swi6 forms MBF complex |
| MEC1 | Sensor kinase in DNA damage checkpoint; yeast ortholog of ATR |
| QCR7 | Subunit of ubiquinol cytochrome c reductase; component of the ETC |
| RAD52 | Required for DNA double-strand break repair and homologous recombination |
| RAD53 | Effector kinase in DNA damage checkpoint; functions downstream of Mec1 |
| RNR1 | Major isoform of large subunit of the RNR complex |
| RNR2 | Small subunit of the RNR complex |
| RNR3 | Minor isoform of large subunit of the RNR complex |
| RNR4 | Small subunit of the RNR complex |
| SML1 | Inhibitor of the RNR complex |
| SWI6 | Transcription factor; subunit of SBF and MBF complexes |
| TEL1 | Sensor kinase in DNA damage checkpoint; yeast ortholog of ATM |
| TOM1 | E3 ubiquitin ligase involved in degradation of excess histones |