Table 3. Meta-analysis of the association between RANK, RANKL, OPG polymorphisms and RA risk.
| SNP | Comparison | Category | Category | Studies | OR (95% CI) | P-value | P for heterogeneity |
|---|---|---|---|---|---|---|---|
| RANK rs1805034 | C vs. T | Total | 3 | 0.99 (0.83, 1.19) | 0.923 | 0.102 | |
| Ethnicity | Caucasians | 2 | 0.92 (0.64, 1.34) | 0.670 | 0.037 | ||
| Chinese | 1 | 1.05 (0.89, 1.24) | 0.551 | – | |||
| SOC | PB | 1 | 0.75 (0.55, 1.02) | 0.066 | – | ||
| HB | 2 | 1.07 (0.95, 1.21) | 0.267 | 0.766 | |||
| CC+TC vs. TT | Total | 3 | 0.99 (0.85, 1.16) | 0.927 | 0.172 | ||
| Ethnicity | Caucasians | 2 | 0.88 (0.70, 1.10) | 0.264 | 0.232 | ||
| Chinese | 1 | 1.11 (0.89, 1.38) | 0.347 | – | |||
| SOC | PB | 1 | 0.71 (0.46, 1.06) | 0.111 | – | ||
| HB | 2 | 1.05 (0.89, 1.24) | 0.590 | 0.406 | |||
| CC vs. TC+TT | Total | 3 | 1.02 (0.72, 1.46) | 0.895 | 0.092 | ||
| Ethnicity | Caucasians | 2 | 1.02 (0.54, 1.91) | 0.949 | 0.048 | ||
| Chinese | 1 | 0.95 (0.64,1.38) | 0.780 | – | |||
| SOC | PB | 1 | 0.70 (0.40, 1.25) | 0.228 | – | ||
| HB | 2 | 1.15 (0.82, 1.62) | 0.415 | 0.148 | |||
| CC vs. TT | Total | 3 | 1.02 (0.81, 1.30) | 0.840 | 0.163 | ||
| Ethnicity | Caucasians | 2 | 0.91 (0.47, 1.76) | 0.785 | 0.057 | ||
| Chinese | 1 | 1.01 (0.68,1.48) | 0.975 | – | |||
| SOC | PB | 1 | 0.62 (0.34, 1.14) | 0.123 | – | ||
| HB | 2 | 1.18 (0.87, 1.45) | 0.381 | 0.465 | |||
| TC vs. TT | Total | 3 | 0.98 (0.83, 1.15) | 0.792 | 0.158 | ||
| Ethnicity | Caucasians | 2 | 0.83 (0.65, 1.05) | 0.123 | 0.642 | ||
| Chinese | 1 | 1.13 (0.90,1.42) | 0.280 | – | |||
| SOC | PB | 1 | 0.75 (0.47, 1.20) | 0.228 | – | ||
| HB | 2 | 1.00 (0.76, 1.31) | 0.991 | 0.131 | |||
| RANKL rs2277438 | G vs. A | Total | 2 | 1.21 (1.00, 1.45) | 0.047 | 0.797 | |
| GG+AG vs. AA | Total | 2 | 1.16 (0.93, 1.45) | 0.179 | 0.746 | ||
| GG vs. AG+AA | Total | 2 | 1.81 (1.09, 3.02) | 0.023 | 0.177 | ||
| GG vs. AA | Total | 2 | 1.90 (1.13, 3.20) | 0.016 | 0.243 | ||
| AG vs. AA | Total | 2 | 1.08 (0.86, 1.36) | 0.515 | 0.492 | ||
| OPG rs3102735 | C vs. T | Total | 5 | 1.22 (0.86, 1.73) | 0.260 | <0.001 | |
| Ethnicity | Asians | 3 | 1.01 (0.70, 1.46) | 0.942 | 0.018 | ||
| Caucasians | 2 | 1.62 (0.83, 3.13) | 0.155 | 0.006 | |||
| SOC | HB | 2 | 1.29 (1.04, 1.60) | 0.023 | 0.251 | ||
| PB | 3 | 1.16 (0.64, 2.13) | 0.621 | <0.001 | |||
| CC+TC vs. TT | Total | 5 | 1.16 (0.85, 1.59) | 0.338 | 0.004 | ||
| Ethnicity | Asians | 3 | 0.97 (0.71, 1.33) | 0.849 | 0.104 | ||
| Caucasians | 2 | 1.52 (0.88, 2.61) | 0.132 | 0.046 | |||
| SOC | HB | 2 | 1.25 (0.98, 1.59) | 0.073 | 0.517 | ||
| PB | 3 | 1.11 (0.65, 1.90) | 0.703 | 0.002 | |||
| CC vs. TC+TT | Total | 5 | 1.73 (0.67, 4.46) | 0.254 | 0.005 | ||
| Ethnicity | Asians | 3 | 1.21 (0.39, 3.72) | 0.745 | 0.036 | ||
| Caucasians | 2 | 3.04 (0.59, 15.70) | 0.183 | 0.050 | |||
| SOC | HB | 2 | 2.38 (0.74, 7.66) | 0.145 | 0.171 | ||
| PB | 3 | 1.43 (0.34, 4.46) | 0.627 | 0.004 | |||
| CC vs. TT | Total | 5 | 1.79 (0.65, 4.89) | 0.259 | 0.002 | ||
| Ethnicity | Asians | 3 | 1.20 (0.36, 3.93) | 0.766 | 0.026 | ||
| Caucasians | 2 | 3.30 (0.58, 18.72) | 0.177 | 0.039 | |||
| SOC | HB | 2 | 2.49 (0.76, 8.20) | 0.133 | 0.164 | ||
| PB | 3 | 1.46 (0.31, 6.93) | 0.634 | 0.002 | |||
| TC vs. TT | Total | 5 | 1.03 (0.88, 1.20) | 0.728 | 0.136 | ||
| Ethnicity | Asians | 3 | 0.91 (0.75, 1.10) | 0.337 | 0.389 | ||
| Caucasians | 2 | 1.27 (0.98, 1.64) | 0.067 | 0.320 | |||
| SOC | HB | 2 | 1.18 (0.92, 1.52) | 0.190 | 0.920 | ||
| PB | 3 | 0.94 (0.77, 1.15) | 0.555 | 0.081 | |||
| OPG rs2073618 | C vs. G | Total | 3 | 1.06 (0.95, 1.19) | 0.295 | 0.998 | |
| Ethnicity | Asians | 2 | 1.07 (0.92, 1.24) | 0.406 | 0.986 | ||
| Caucasians | 1 | 1.06 (0.89, 1.26) | 0.522 | – | |||
| SOC | PB | 2 | 1.07 (0.92, 1.24) | 0.406 | 0.986 | ||
| HB | 1 | 1.06 (0.89, 1.26) | 0.522 | – | |||
| CC+GC vs. GG | Total | 1.10 (0.94, 1.30) | 0.226 | 0.982 | |||
| Ethnicity | Asians | 2 | 1.10 (0.91, 1.34) | 0.303 | 0.851 | ||
| Caucasians | 1 | 1.10 (0.81, 1.50) | 0.525 | – | |||
| SOC | PB | 2 | 1.10 (0.91, 1.34) | 0.303 | 0.851 | ||
| HB | 1 | 1.10 (0.81, 1.50) | 0.525 | – | |||
| CC vs. GC+GG | Total | 1.04 (0.84, 1.30) | 0.709 | 0.896 | |||
| Ethnicity | Asians | 2 | 1.00 (0.69, 1.46) | 0.982 | 0.687 | ||
| Caucasians | 1 | 1.06 (0.81, 1.39) | 0.659 | – | |||
| SOC | PB | 2 | 1.00 (0.69, 1.46) | 0.982 | 0.687 | ||
| HB | 1 | 1.06 (0.81, 1.39) | 0.659 | – | |||
| CC vs. GG | Total | 1.09 (0.84, 1.42) | 0.503 | 0.915 | |||
| Ethnicity | Asians | 2 | 1.05 (0.71, 1.55) | 0.800 | 0.751 | ||
| Caucasians | 1 | 1.13 (0.79, 1.62) | 0.489 | – | |||
| SOC | PB | 2 | 1.05 (0.71, 1.55) | 0.800 | 0.751 | ||
| HB | 1 | 1.13 (0.79, 1.62) | 0.489 | – | |||
| GC vs. GG | Total | 1.11 (0.94, 1.31) | 0.237 | 0.945 | |||
| Ethnicity | Asians | 2 | 1.11 (0.91, 1.36) | 0.286 | 0.750 | ||
| Caucasians | 1 | 1.09 (0.79, 1.51) | 0.600 | – | |||
| SOC | PB | 2 | 1.11 (0.91, 1.36) | 0.286 | 0.750 | ||
| HB | 1 | 1.09 (0.79, 1.51) | 0.600 | – | |||
| OPG rs3134069 | C vs. A | Total | 2 | 0.79 (0.50, 1.25) | 0.310 | 0.787 | |
| CC+AC vs. AA | Total | 2 | 0.78 (0.48, 1.26) | 0.305 | 0.580 | ||
| CC vs. AC+AA | Total | 2 | 0.76 (0.13, 4.52) | 0.766 | 0.434 | ||
| CC vs. AA | Total | 2 | 0.72 (0.12, 4.33) | 0.724 | 0.457 | ||
| AC vs. AA | Total | 2 | 0.78 (0.47, 1.28) | 0.320 | 0.435 |
Abbreviations: HB, hospital based; PB, public based.