Skip to main content
. 2019 Jun 28;39(6):BSR20182356. doi: 10.1042/BSR20182356

Table 3. Meta-analysis of the association between RANK, RANKL, OPG polymorphisms and RA risk.

SNP Comparison Category Category Studies OR (95% CI) P-value P for heterogeneity
RANK rs1805034 C vs. T Total 3 0.99 (0.83, 1.19) 0.923 0.102
Ethnicity Caucasians 2 0.92 (0.64, 1.34) 0.670 0.037
Chinese 1 1.05 (0.89, 1.24) 0.551
SOC PB 1 0.75 (0.55, 1.02) 0.066
HB 2 1.07 (0.95, 1.21) 0.267 0.766
CC+TC vs. TT Total 3 0.99 (0.85, 1.16) 0.927 0.172
Ethnicity Caucasians 2 0.88 (0.70, 1.10) 0.264 0.232
Chinese 1 1.11 (0.89, 1.38) 0.347
SOC PB 1 0.71 (0.46, 1.06) 0.111
HB 2 1.05 (0.89, 1.24) 0.590 0.406
CC vs. TC+TT Total 3 1.02 (0.72, 1.46) 0.895 0.092
Ethnicity Caucasians 2 1.02 (0.54, 1.91) 0.949 0.048
Chinese 1 0.95 (0.64,1.38) 0.780
SOC PB 1 0.70 (0.40, 1.25) 0.228
HB 2 1.15 (0.82, 1.62) 0.415 0.148
CC vs. TT Total 3 1.02 (0.81, 1.30) 0.840 0.163
Ethnicity Caucasians 2 0.91 (0.47, 1.76) 0.785 0.057
Chinese 1 1.01 (0.68,1.48) 0.975
SOC PB 1 0.62 (0.34, 1.14) 0.123
HB 2 1.18 (0.87, 1.45) 0.381 0.465
TC vs. TT Total 3 0.98 (0.83, 1.15) 0.792 0.158
Ethnicity Caucasians 2 0.83 (0.65, 1.05) 0.123 0.642
Chinese 1 1.13 (0.90,1.42) 0.280
SOC PB 1 0.75 (0.47, 1.20) 0.228
HB 2 1.00 (0.76, 1.31) 0.991 0.131
RANKL rs2277438 G vs. A Total 2 1.21 (1.00, 1.45) 0.047 0.797
GG+AG vs. AA Total 2 1.16 (0.93, 1.45) 0.179 0.746
GG vs. AG+AA Total 2 1.81 (1.09, 3.02) 0.023 0.177
GG vs. AA Total 2 1.90 (1.13, 3.20) 0.016 0.243
AG vs. AA Total 2 1.08 (0.86, 1.36) 0.515 0.492
OPG rs3102735 C vs. T Total 5 1.22 (0.86, 1.73) 0.260 <0.001
Ethnicity Asians 3 1.01 (0.70, 1.46) 0.942 0.018
Caucasians 2 1.62 (0.83, 3.13) 0.155 0.006
SOC HB 2 1.29 (1.04, 1.60) 0.023 0.251
PB 3 1.16 (0.64, 2.13) 0.621 <0.001
CC+TC vs. TT Total 5 1.16 (0.85, 1.59) 0.338 0.004
Ethnicity Asians 3 0.97 (0.71, 1.33) 0.849 0.104
Caucasians 2 1.52 (0.88, 2.61) 0.132 0.046
SOC HB 2 1.25 (0.98, 1.59) 0.073 0.517
PB 3 1.11 (0.65, 1.90) 0.703 0.002
CC vs. TC+TT Total 5 1.73 (0.67, 4.46) 0.254 0.005
Ethnicity Asians 3 1.21 (0.39, 3.72) 0.745 0.036
Caucasians 2 3.04 (0.59, 15.70) 0.183 0.050
SOC HB 2 2.38 (0.74, 7.66) 0.145 0.171
PB 3 1.43 (0.34, 4.46) 0.627 0.004
CC vs. TT Total 5 1.79 (0.65, 4.89) 0.259 0.002
Ethnicity Asians 3 1.20 (0.36, 3.93) 0.766 0.026
Caucasians 2 3.30 (0.58, 18.72) 0.177 0.039
SOC HB 2 2.49 (0.76, 8.20) 0.133 0.164
PB 3 1.46 (0.31, 6.93) 0.634 0.002
TC vs. TT Total 5 1.03 (0.88, 1.20) 0.728 0.136
Ethnicity Asians 3 0.91 (0.75, 1.10) 0.337 0.389
Caucasians 2 1.27 (0.98, 1.64) 0.067 0.320
SOC HB 2 1.18 (0.92, 1.52) 0.190 0.920
PB 3 0.94 (0.77, 1.15) 0.555 0.081
OPG rs2073618 C vs. G Total 3 1.06 (0.95, 1.19) 0.295 0.998
Ethnicity Asians 2 1.07 (0.92, 1.24) 0.406 0.986
Caucasians 1 1.06 (0.89, 1.26) 0.522
SOC PB 2 1.07 (0.92, 1.24) 0.406 0.986
HB 1 1.06 (0.89, 1.26) 0.522
CC+GC vs. GG Total 1.10 (0.94, 1.30) 0.226 0.982
Ethnicity Asians 2 1.10 (0.91, 1.34) 0.303 0.851
Caucasians 1 1.10 (0.81, 1.50) 0.525
SOC PB 2 1.10 (0.91, 1.34) 0.303 0.851
HB 1 1.10 (0.81, 1.50) 0.525
CC vs. GC+GG Total 1.04 (0.84, 1.30) 0.709 0.896
Ethnicity Asians 2 1.00 (0.69, 1.46) 0.982 0.687
Caucasians 1 1.06 (0.81, 1.39) 0.659
SOC PB 2 1.00 (0.69, 1.46) 0.982 0.687
HB 1 1.06 (0.81, 1.39) 0.659
CC vs. GG Total 1.09 (0.84, 1.42) 0.503 0.915
Ethnicity Asians 2 1.05 (0.71, 1.55) 0.800 0.751
Caucasians 1 1.13 (0.79, 1.62) 0.489
SOC PB 2 1.05 (0.71, 1.55) 0.800 0.751
HB 1 1.13 (0.79, 1.62) 0.489
GC vs. GG Total 1.11 (0.94, 1.31) 0.237 0.945
Ethnicity Asians 2 1.11 (0.91, 1.36) 0.286 0.750
Caucasians 1 1.09 (0.79, 1.51) 0.600
SOC PB 2 1.11 (0.91, 1.36) 0.286 0.750
HB 1 1.09 (0.79, 1.51) 0.600
OPG rs3134069 C vs. A Total 2 0.79 (0.50, 1.25) 0.310 0.787
CC+AC vs. AA Total 2 0.78 (0.48, 1.26) 0.305 0.580
CC vs. AC+AA Total 2 0.76 (0.13, 4.52) 0.766 0.434
CC vs. AA Total 2 0.72 (0.12, 4.33) 0.724 0.457
AC vs. AA Total 2 0.78 (0.47, 1.28) 0.320 0.435

Abbreviations: HB, hospital based; PB, public based.

HHS Vulnerability Disclosure