Table 2. KEGG signaling pathways significantly enriched in KBD compared with RA.
| KEEG pathway | Number of genes (%) | P-value* |
|---|---|---|
| Up-regulation | ||
| MAPK signaling pathway | 3 (20) | 4.8 × 10−2 |
| Down-regulation | ||
| TLR signaling pathway | 12 (7.9) | 2.3 × 10−5 |
| Jak-STAT signaling pathway | 14 (9.2) | 6.7 × 10−5 |
| Leukocyte transendothelial migration | 11 (7.2) | 4.5 × 10−4 |
| NOD-like receptor signaling pathway | 8 (5.3) | 6.0 × 10−4 |
| T-cell receptor signaling pathway | 10 (6.6) | 9.8 × 10−4 |
| Chemokine signaling pathway | 13 (8.6) | 1.5 × 10−3 |
*
Nominal P-value was calculated by hypergeometric test.