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. 2019 Jun 28;39(6):BSR20190857. doi: 10.1042/BSR20190857

Figure 5. Effect of higenamine on the production of MMPs and ADAMTSs in IL-1β-induced NPCs.

Figure 5

NPCs were stimulated with IL-1β (10 ng/ml) for 24 h with or without the pretreatment of higenamine (10, 20, 40 μM) for 2 h. The production of matrix degrading enzymes including MMP-3 (A), MMP-13 (B), ADAMTS-4 (C), and ADAMTS-5 (D) in cell culture was determined using ELISA. (E) The protein expressions of MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 were determined using Western blot. *P < 0.05 vs. control NPCs. #P < 0.05 vs. IL-1β-stimulated NPCs.