Figure 1.

The major strategies employed in resistance management for microbes and other organisms with the predicted potential impact on the distribution of resistance. Where different terminology is in use in different disciplines, both terms have been provided (cycling = rotations; mixing = mosaics). Note that mixing and combination approaches work better if microbes are cleared from treated patients and if transmission occurs predominantly from untreated individuals. This can readily break down for commensal bacteria that are not the main target of therapy, but which can cause nosocomial infections in different individuals