Figure 2.

The critical assumptions of the major strategies of resistance management. Here, compensation refers to the process whereby additional mutations reduce the fitness cost associated with the acquisition of new mutations, or the costs associated with plasmids carrying resistance genes. All multidrug approaches rely on low initial frequencies and lack of cross‐resistance between drugs, where a single resistance trait give protection against multiple drugs. For combinations, ideally there must also be no synergistic interactions between drugs, and similar persistence in the body, see text for details