Table 1.
Changes in gene expression in DGKη-KO mouse cerebral cortex.
| Gene | Gene name | Fold-change (log2) | SEM | P value |
|---|---|---|---|---|
| Prl | prolactin | 5.4 | ±1.7 | 0.031 |
| Gh | growth hormone | 5.3 | ±1.8 | 0.042 |
| Adamts19 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19 | 2.9 | ±0.4 | 0.002 |
| Kqt2 | potassium channel, KvQLT family | 2.3 | ±0.7 | 0.032 |
| Foxp3 | forkhead box P3 | 2.3 | ±0.7 | 0.031 |
| AMPD3 | adenosine monophosphate deaminase 3 | 2.2 | ±0.3 | 0.003 |
| Top2a | topoisomerase (DNA) II alpha | 1.5 | ±0.4 | 0.026 |
| Smim6 | small integral membrane protein 6 | 1.5 | ±0.2 | 0.002 |
| Tomt | transmembrane O-methyltransferase | 1.5 | ±0.3 | 0.007 |
| Eqtn | equatorin, sperm acrosome associated | 1.5 | ±0.5 | 0.037 |
| Cnot4 | CCR4-NOT transcription complex subunit 4 | 1.4 | ±0.1 | 0.001 |
| Fpr2 | N-formyl peptide receptor 2 | 1.4 | ±0.2 | 0.001 |
| Glp1r | glucagon-like peptide 1 receptor | 1.4 | ±0.4 | 0.022 |
| Hif3a | hypoxia inducible factor 3, alpha subunit | 1.2 | ±0.1 | <0.001 |
| Atp13a4 | ATPase type 13A4 | 1.2 | ±0.0 | <0.001 |
| Arg1 | arginase | 1.2 | ±0.2 | 0.004 |
| Slc5a8 | solute carrier family 5 (iodide transporter), member 8 | 1.2 | ±0.4 | 0.040 |
| Lrrc17 | leucine rich repeat containing 17 | 1.2 | ±0.3 | 0.009 |
| Bub1 | BUB1, mitotic checkpoint serine/threonine kinase | 1.2 | ±0.4 | 0.037 |
| Ppp1r3e | protein phosphatase 1, regulatory (inhibitor) subunit 3E | 1.2 | ±0.3 | 0.017 |
| Spaca1 | sperm acrosome associated 1 | 1.1 | ±0.2 | 0.003 |
| Il1b | interleukin 1 beta | 1.1 | ±0.2 | 0.011 |
| Rhbdl2 | rhomboid like 2 | 1.1 | ±0.2 | 0.012 |
| Rbmy | RNA binding motif protein, Y chromosome | 1.0 | ±0.2 | 0.013 |
| Dscaml1 | DS cell adhesion molecule like 1 | 1.0 | ±0.2 | 0.010 |
| Thpo | thrombopoietin | 1.0 | ±0.3 | 0.028 |
| Fut1 | fucosyltransferase 1 | −1.0 | ±0.1 | 0.003 |
| Prrg1 | proline rich Gla (G-carboxyglutamic acid) 1 | −1.0 | ±0.2 | 0.006 |
| Ces2c | carboxylesterase 2C | −1.0 | ±0.2 | 0.011 |
| Igk-V21-4 | immunoglobulin kappa chain variable 21 - 4 | −1.0 | ±0.3 | 0.025 |
| Gnat3 | guanine nucleotide binding protein, alpha transducing 3 | −1.0 | ±0.2 | 0.004 |
| Cryba1 | crystallin, beta A1 | −1.0 | ±0.2 | 0.002 |
| Neurog1 | neurogenin 1 | −1.0 | ±0.1 | <0.001 |
| Rnf130 | ring finger protein 130 | −1.1 | ±0.3 | 0.024 |
| Defb26 | defensin beta 26 | −1.1 | ±0.2 | 0.005 |
| F7 | coagulation factor VII | −1.1 | ±0.2 | 0.009 |
| Siglecf | sialic acid binding Ig-like lectin F | −1.1 | ±0.2 | 0.009 |
| – | BApecB1a-P19 IgG heavy chain | −1.2 | ±0.3 | 0.016 |
| Trim63 | tripartite motif-containing 63 | −1.2 | ±0.3 | 0.014 |
| Serpinf2 | serine peptidase inhibitor F member 2 | −1.2 | ±0.3 | 0.015 |
| Bsx | brain specific homeobox | −1.2 | ±0.3 | 0.009 |
| Vsig4 | V-set and immunoglobulin domain containing 4 | −1.3 | ±0.4 | 0.020 |
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | −1.6 | ±0.2 | 0.002 |
All genes meeting the cut-off (see Materials and Methods) in the DGKη-KO mouse cerebral cortexes were analyzed. The values (fold-change, log2) are presented as the mean ± SEM of three animals per genotype (WT: n = 3, KO: n = 3).