Table 2.

Biological pathways affected in the DGKη-KO mouse cerebral cortex.

Database category	Biological pathway	P-value	Gene Count	Genes
GOTERM_BP	Positive regulation of transcription by RNA polymerase II (GO:0045944)	0.004	8	Bsx, Foxp3d, Glp1re,Hif3a, Il1bf, Neurog1, Serpinf2,
KEGG_PATHWAY	Neuroactive ligand-receptor Interaction (mmu04080)	0.031	4	Fpr2, Glp1re, Ghg,Prlh
GOTERM_BP	Positive regulation of cytosolic calcium ion concentrationa (GO:0007204)	0.039	3	Fpr2, Glp1re, Il1bf,
KEGG_PATHWAY	Jak-STAT signaling pathwayb (mmu04630)	0.049	3	Ghg, Prlh, Thpo
GOTERM_BP	Positive regulation of ERK1 and ERK2 cascadec (GO:0070374)	0.059	3	Il1bf, Serpinf2, Thpo

For each term, an EASE score cut-off of P-value <0.1 was applied along with gene count ≥3. Along with database category for GO and KEGG using DAVID, Benjamini false discovery rate-corrected P-value, gene count and gene lists are presented. Genes and biological pathways implicated in BPD are indicated in bold font.

^a[31].

^b[[32], [33], [34]].

^c[35,36].

^d[37,38].

^e[28,29].

^f[27].

^g[26].

^h[39,40].