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. 2019 Jul;127:323–338. doi: 10.1016/j.nbd.2019.03.018

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© 2019 MRC Laboratory of Molecular Biology

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Ventricular dilation, hippocampal atrophy and neuronal loss in R962-hTau rats.

(A) Coronal brain sections of an 18-month-old control, a 10-month-old R962-hTau and an 18-month-old R962-hTau rat demonstrating the extensive tau pathology-dependent ventricular dilation and hippocampal atrophy in the R962-hTau rats by 18-months of age. (B) Volumetric analysis of the lateral ventricles, forebrain and dorsal hippocampus of 18-months old rats (n = 8/group) show that ventricular volumes increase (left panels) while forebrain (top right panel) and hippocampal volumes decrease in R962-hTau rats (bottom right panel). AP coordinates 1.75 to 0.75 (forebrain); −2.30 to −4.20 (dorsal hippocampus)(Paxinos and Watson, 2007). (C) Representative images of transverse and coronal maximum intensity projections from T2-weighted MRI studies in 15-month-old animals, demonstrating ventricular dilation confirming histological observations and demonstrating these features are initiated by 15-months of age (n = 1/group). (D) Representative images of CA1 (top panel) and CA2 (bottom panel) of 18-month-old control, 10-month-old R962-hTau and 18-month-old R962-hTau rats, illustrating the marked neuronal loss and disorganization of the hippocampus. (E) Neuron counts based on average NeuN-immunoreactive nuclei per field of view (FOV) were generated from 3 images for each section for CA1 (top) and CA2 (bottom) (n = 7–8/group). Values are expressed as means ± SEM. Independent t-tests and Mann Whitney U tests were used where appropriate. **p < .01, ***p < .001 Scale bar: A, 1000 μm; D, 50 μm.