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. 2019 Jun 21;11:149. doi: 10.3389/fnagi.2019.00149

Figure 2.

Figure 2

Chronic treatment with CM-695 reversed learning deficits in aged Tg2576 mice. (A) Scheme showing timeline for treatment, behavioral tasks, and killing of mice. FC, fear conditioning; MWM, Morris water maze; rMWM, reversal MWM; Sac, sacrificed. (B) Freezing behavior from Tg2576 mice treated with vehicle (n = 10) or CM-695 (n = 11). Data represent the percentage of time of freezing during a 2 min test. (C) Escape latency of the hidden platform in the MWM test for the Tg2576 mice treated with vehicle (n = 10) or CM-695 (n = 11). (D) Percentage of time spent in correct quadrant during the probe test (days 4, 7, and 9). (E) Escape latency during the rMWM test for the Tg2576 mice treated with vehicle (n = 10) or CM-695 (n = 11) after the washout period. (F) Percentage of time spent in correct quadrant during the probe test after rMWM phase (day 6). In all figures results are expressed as mean ± SEM; *p < 0.05, **p < 0.01.