. 2019 Jun 18;69(4):953–961. doi: 10.3233/JAD-181285

Table 1.

Demographics and disease features

	TDP-43 groups			LB groups
	TDP-43 positive (n = 121)	TDP-43 negative (n = 100)	Group comparison	LB-positive (n = 98)	LB-negative (n = 123)	Group comparison
Age	76.46 (9.23)	74.24 (10.32)	t(219) = –1.689, p = 0.093	73.92 (9.53)	76.68 (9.84)	t(219) = 2.104, p = 0.037^*
Age at death	82.52 (9.34)	79.97 (10.40)	t(219) = –1.919, p = 0.056	80.01 (9.90)	82.45 (9.80)	t(219) = 1.828, p = 0.069
Education, years	15.25 (3.21)	15.77 (2.86)	t(219) = 1.2256, p = 0.210	16.04 (2.87)	15.04 (3.15)	t(219) = –2.434, p = 0.016^*
Gender (female %)	55.4	45.0	χ² = 2.356, p = 0.125	49.0	52.0	χ² = 0.203, p = 0.652
Handedness (right %)	91.7	94.0	χ² = 1.715, p = 0.424	93.9	91.9	χ² = 0.472, p = 0.790
APOE ɛ4 carriers (%)	66.0	57.4	χ² = 4.357, p = 0.113	71.7	54.0	χ² = 8.382, p = 0.015^*
Hippocampal sclerosis (%)	34.1	10.0	χ2 = 18.212, p = 0.000^*	21.6	24.4	χ² = 1.661, p = 0.646
Thal phase for amyloid plaques (A score) (1/2/3 %)	3.4/18.2/78.5	1.0/38.4/60.6	χ² = 14.852, p = 0.005^*	1.0/17.3/81.6	3.2/35.2/61.5	χ² = 11.645, p = 0.020^*
Braak stage for neurofibrillary degeneration (B score) (3/4/5/6 %)	4.2/5.0/22.5/68.3	1.0/4.0/34.0/61.0	χ² = 5.178, p = 0.159	1.0/4.1/24.5/70.4	4.1/4.9/30.3/60.7	χ² = 3.435, p = 0.329
Density of neocortical neuritic plaques (CERAD score) (C score) (1/2/3 %)	2.5/11.6/86.0	3.0/24.2/72.7	χ² = 6.313, p = 0.043^*	1.0/11.2/87.8	4.1/22.1/73.8	χ² = 6.959 p = 0.031^*
Density of diffuse plaques (CERAD semiquantitative score) (1/2/3 %)	1.7/12.8/85.5	2.1/10.6/87.2	χ² = 0.276, p = 0.871	3.3/12.0/84.8	0.8/11.8/87.4	χ² = 1.646, p = 0.439
CDR sum of boxes score	6.92 (4.27)	6.03 (3.83)	t(219) = –1.610, p = 0.109	6.99 (4.54)	6.14 (3.68)	t(219) = –1.542, p = 0.125

All variables are reported as mean (standard deviation) or percentage where stated. Statistical significance is marked with ^*.