Table 2.
NPI-Q scores of the groups and statistical results
| TDP-43 groups | LB groups | TDP-43 and LB | TDP-43 and diffuse | LB and diffuse | |||||
| TDP-43 positive (n = 116) | TDP-43 negative (n = 99) | Group comparison | LB-positive (n = 102) | LB-negative (n = 113) | Group comparison | interaction | plaque density interaction | plaque density interaction | |
| NPI-Q total score | 3.88 (4.09) | 4.06 (4.17) | F(1,191) = 24.315, p = 0.213 | 4.42 (4.64) | 3.60 (3.63) | F(1,191) = 7.745, p = 0.006* | F(1,191) = 0.923, p = 0.338 | F(2,191) = 10.446, p = 0.000* | F(2,191) = 5.114, p = 0.007* |
| Symptom presence (%) | |||||||||
| Delusion | 9.1 | 12.0 | χ2 = 0.497, p = 0.481 | 11.2 | 9.8 | χ2 = 0.126, p = 0.722 | n/a | n/a | n/a |
| Hallucination | 6.6 | 5.0 | χ2 = 0.257, p = 0.612 | 5.7 | 6.1 | χ2 = 0.018, p = 0.892 | n/a | n/a | n/a |
| Agitation | 24.0 | 36.0 | χ2 = 3.818, p = 0.051 | 28.6 | 30.1 | χ2 = 0.060, p = 0.807 | n/a | n/a | n/a |
| Depression | 32.2 | 38.0 | χ2 = 0.803, p = 0.370 | 38.8 | 31.7 | χ2 = 1.200, p = 0.273 | n/a | n/a | n/a |
| Anxiety | 34.7 | 40.0 | χ2 = 0.656, p = 0.418 | 46.9 | 29.3 | χ2 = 7.298, p = 0.007* | n/a | n/a | n/a |
| Euphoria | 1.7 | 3 | χ2 = 0.449, p = 0.503 | 3.1 | 1.6 | χ2 = 0.508, p = 0.476 | n/a | n/a | n/a |
| Apathy | 35.5 | 35.0 | χ2 = 0.007, p = 0.934 | 36.7 | 34.1 | χ2 = 0.160, p = 0.689 | n/a | n/a | n/a |
| Disinhibition | 20.7 | 22.0 | χ2 = 0.059, p = 0.809 | 25.5 | 17.9 | χ2 = 1.893, p = 0.169 | n/a | n/a | n/a |
| Irritability | 29.8 | 41.0 | χ2 = 3.051, p = 0.081 | 31.6 | 37.4 | χ2 = 0.799, p = 0.371 | n/a | n/a | n/a |
| Aberrant motor behavior | 14.0 | 12.0 | χ2 = 0.202, p = 0.653 | 13.3 | 13.0 | χ2 = 0.003, p = 0.955 | n/a | n/a | n/a |
| Sleep behavior problems | 28.1 | 21.0 | χ2 = 1.476, p = 0.224 | 24.5 | 25.2 | χ2 = 0.015, p = 0.903 | n/a | n/a | n/a |
| Appetite | 25.6 | 22.0 | χ2 = 0.394, p = 0.530 | 25.5 | 22.8 | χ2 = 0.226, p = 0.635 | n/a | n/a | n/a |
| Severity | |||||||||
| Delusion | 1.36 (0.51) | 1.75 (0.75) | F(1,191) = 0.114, p = 0.736 | 1.64 (0.67) | 1.50 (0.67) | F(1,191) = 0.022, p = 0.883 | F(1,191) = 0.052, p = 0.820 | F(2,191) = 0.326, p = 0.723 | F(2,191) = 0.326, p = 0.722 |
| Hallucination | 1.38 (0.74) | 1.80 (0.84) | F(1,191) = 1.955, p = 0.164 | 1.83 (0.75) | 1.29 (0.76) | F(1,191) = 1.574, p = 0.211 | F(1,191) = 2.767, p = 0.098 | F(2,191) = 1.395, p = 0.250 | F(2,191) = 1.952, p = 0.145 |
| Agitation | 1.48 (0.69) | 1.47 (0.56) | F(1,191) = 0.005, p = 0.942 | 1.32 (0.48) | 1.59 (0.69) | F(1,191) = 1.472, p = 0.227 | F(1,191) = 0.588, p = 0.444 | F(2,191) = 1.940, p = 0.147 | F(2,191) = 1.675, p = 0.190 |
| Depression | 1.36 (0.67) | 1.45 (0.60) | F(1,191) = 3.958, p = 0.048* | 1.50 (0.68) | 1.31 (0.57) | F(1,191) = 3.066, p = 0.082 | F(1,191) = 0.089, p = 0.766 | F(2,191) = 5.491, p = 0.005* | F(2,191) = 2.445, p = 0.089 |
| Anxiety | 1.52 (0.71) | 1.40 (0.59) | F(1,191) = 0.963, p = 0.328 | 1.48 (0.66) | 1.44 (0.65) | F(1,191) = 4.121, p = 0.044* | F(1,191) = 0.000, p = 0.991 | F(2,191) = 5.490, p = 0.005* | F(2,191) = 2.304, p = 0.103 |
| Euphoria | 1 (0) | 1 (0) | F(1,191) = 0.040, p = 0.841 | 1 (0) | 1 (0) | F(1,191) = 0.175, p = 0.676 | F(1,191) = 0.058, p = 0.810 | F(2,191) = 0.053, p = 0.949 | F(2,191) = 0.029, p = 0.971 |
| Apathy | 1.65 (0.72) | 1.63 (0.69) | F(1,191) = 0.931, p = 0.336 | 1.58 (0.69) | 1.69 (0.72) | F(1,191) = 10.328, p = 0.002* | F(1,191) = 0.833, p = 0.363 | F(2,191) = 0.950, p = 0.388 | F(2,191) = 6.571, p = 0.002* |
| Disinhibition | 1.96 (0.74) | 1.36 (0.66) | F(1,191) = 1.051, p = 0.307 | 1.80 (0.76) | 1.55 (0.74) | F(1,191) = 0.634, p = 0.427 | F(1,191) = 1.578, p = 0.211 | F(2,191) = 1.238, p = 0.292 | F(2,191) = 2.426, p = 0.091 |
| Irritability | 1.36 (0.59) | 1.46 (0.64) | F(1,191) = 1.426, p = 0.234 | 1.61 (0.72) | 1.28 (0.50) | F(1,191) = 3.930, p = 0.049* | F(1,191) = 0.197, p = 0.658 | F(2,191) = 8.457, p = 0.000* | F(2,191) = 6.678, p = 0.002* |
| Aberrant motor behavior | 1.47 (0.72) | 1.42 (0.67) | F(1,191) = 9.164, p = 003* | 1.62 (0.77) | 1.31 (0.60) | F(1,191) = 002, p = 0.961 | F(1,191) = 5.245, p = 0.023* | F(2,191) = 6.342, p = 0.002* | F(2,191) = 0.493, p = 0.612 |
| Sleep behavior problems | 1.65 (0.69) | 1.62 (0.81) | F(1,191) = 3.205, p = 0.075 | 1.83 (0.82) | 1.48 (0.63) | F(1,191) = 4.543, p = 0.034* | F(1,191) = 0.777, p = 0.379 | F(2,191) = 4.882, p = 0.009* | F(2,191) = 3.017, p = 0.051 |
| Appetite | 1.52 (0.72) | 1.41 (0.67) | F(1,191) = 0.484, p = 0.487 | 1.56 (0.77) | 1.39 (0.63) | F(1,191) = 4.278, p = 0.040* | F(1,191) = 0.923, p = 0.338 | F(2,191) = 9.635, p = 0.000* | F(2,191) = 2.556, p = 0.080 |
All variables are reported as mean (standard deviation) or percentage where stated. Statistical significance is marked with *. n/a, not applicable; multivariate analysis of covariance was only run for quantitative variables.